Display Settings:

Format

Send to:

Choose Destination

    KAT6B K(lysine) acetyltransferase 6B [ Homo sapiens ]

    Gene ID: 23522, updated on 11-May-2012

    Summary

    Official Symbol
    KAT6Bprovided by HGNC
    Official Full Name
    K(lysine) acetyltransferase 6Bprovided by HGNC
    Primary source
    HGNC:17582
    See related
    Ensembl:ENSG00000156650; HPRD:07065; MIM:605880; Vega:OTTHUMG00000018509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    qkf; MORF; MOZ2; GTPTS; MYST4; querkopf; FLJ90335; KIAA0383; DKFZp313G1618
    Summary
    The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

    Genomic context

    Location :
    10q22.2
    Sequence :
    Chromosome: 10; NC_000010.10 (76586379..76792639)
    See KAT6B in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene adenosine kinase Neighboring gene polymerase (RNA) III (DNA directed) polypeptide D, 44kDa pseudogene Neighboring gene family with sequence similarity 32, member C (pseudogene) Neighboring gene dual specificity phosphatase and pro isomerase domain containing 1 Neighboring gene peptidylprolyl isomerase A (cyclophilin A) pseudogene 13

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysines (K264, K266, K273) in the carboxy-terminus of integrase PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8WYB5 P54259 ATN1    HPRD  PubMed  
    Q8WYB5 Q01196 RUNX1    HPRD  PubMed  
    Q8WYB5 Q13950 RUNX2    HPRD  PubMed  
    BioGRID:117069 BioGRID:124016 ING5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117069 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117069 BioGRID:107308 RUNX2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:117069 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosome assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    histone acetyltransferase KAT6B
    Names
    histone acetyltransferase KAT6B
    MYST-4
    MOZ-related factor
    histone acetyltransferase MORF
    histone acetyltransferase MOZ2
    histone acetyltransferase MYST4
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
    MYST histone acetyltransferase (monocytic leukemia) 4
    monocytic leukemia zinc finger protein-related factor
    NP_036462.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032048.1 RefSeqGene

      Range
      5001..211210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256468.1NP_001243397.1  histone acetyltransferase KAT6B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF119230, AF217500, BC150618, DA488537
      UniProtKB/TrEMBL
      B2RWN8
      UniProtKB/Swiss-Prot
      Q8WYB5
      Conserved Domains (5) summary
      PLN03238
      Location:538806
      Blast Score: 900
      PLN03238; probable histone acetyltransferase MYST; Provisional
      pfam01853
      Location:590777
      Blast Score: 896
      MOZ_SAS; MOZ/SAS family
      cl00073
      Location:113167
      Blast Score: 131
      H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
      cl02608
      Location:294362
      Blast Score: 111
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
      cl15348
      Location:215272
      Blast Score: 118
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_001256469.1NP_001243398.1  histone acetyltransferase KAT6B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF113514, AF217500, BC150618, DA488537
      UniProtKB/TrEMBL
      B2RWN8
      UniProtKB/Swiss-Prot
      Q8WYB5
      Conserved Domains (5) summary
      PLN03238
      Location:429697
      Blast Score: 899
      PLN03238; probable histone acetyltransferase MYST; Provisional
      pfam01853
      Location:481668
      Blast Score: 895
      MOZ_SAS; MOZ/SAS family
      cl00073
      Location:113167
      Blast Score: 132
      H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
      cl02608
      Location:294362
      Blast Score: 110
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
      cl15348
      Location:215272
      Blast Score: 117
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. NM_012330.3NP_036462.2  histone acetyltransferase KAT6B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF217500, BC014143, BC150618, DA488537
      Consensus CDS
      CCDS7345.1
      UniProtKB/TrEMBL
      B2RWN8
      UniProtKB/Swiss-Prot
      Q8WYB5
      Related
      ENSP00000287239, OTTHUMP00000019868, ENST00000287239, OTTHUMT00000048771
      Conserved Domains (5) summary
      PLN03238
      Location:721989
      Blast Score: 900
      PLN03238; probable histone acetyltransferase MYST; Provisional
      pfam01853
      Location:773960
      Blast Score: 896
      MOZ_SAS; MOZ/SAS family
      cl00073
      Location:113167
      Blast Score: 130
      H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...
      cl02608
      Location:294362
      Blast Score: 111
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
      cl15348
      Location:215272
      Blast Score: 120
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      76586379..76792639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      70584711..70791213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC018511.5 (71990..117442) None
    genomic AC063962.11 None
    genomic CH471083.1 EAW54557.1
      EAW54558.1
      EAW54559.1
    mRNA AA416904.1 None
    mRNA AB002381.2 BAA20837.2
    mRNA AF113514.1 AAF00095.1
    mRNA AF119230.1 AAF00099.1
    mRNA AF119231.1 AAF00100.1
    mRNA AF217500.1 AAL56647.1
    mRNA AK074816.1 None
    mRNA AL832065.1 CAH10408.1
    mRNA BC014143.2 AAH14143.1
    mRNA BC021128.1 AAH21128.1
    mRNA BC048199.1 AAH48199.1
    mRNA BC150270.1 AAI50271.1
    mRNA BC150618.1 AAI50619.1
    mRNA DA488537.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69YR9 GenPept UniProtKB/TrEMBL:Q69YR9
    Q8WYB5.3 GenPept UniProtKB/Swiss-Prot:Q8WYB5

      Supplemental Content

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...