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    KAT7 K(lysine) acetyltransferase 7 [ Homo sapiens ]

    Gene ID: 11143, updated on 11-May-2012
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    Summary

    Official Symbol
    KAT7provided by HGNC
    Official Full Name
    K(lysine) acetyltransferase 7provided by HGNC
    Primary source
    HGNC:17016
    See related
    Ensembl:ENSG00000136504; HPRD:07135; MIM:609880; Vega:OTTHUMG00000161770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HBO1; HBOA; MYST2
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    Genomic context

    Location :
    17q21.32
    Sequence :
    Chromosome: 17; NC_000017.10 (47865981..47906458)
    See KAT7 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member B1 Neighboring gene family with sequence similarity 117, member A Neighboring gene uncharacterized LOC729220 Neighboring gene tachykinin 4 (hemokinin) Neighboring gene mRNA turnover 4 homolog (S. cerevisiae) pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation. Avvakumov N, et al. Mol Cell Biol, 2012 Feb. PMID 22144582.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Miotto B, et al. Mol Cell, 2011 Oct 7. PMID 21856198.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (40) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The protein domains required for the assembly and function of HBO1/ING complexes were shown. Multiple PHD finger domains in different subunits bound the histone H3 N-terminal tail with a specificity towards lysine 4 methylation.
      Title: Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation.
    2. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress
      Title: JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.
    3. HBO1 was an important downstream molecule of ERalpha.
      Title: Estrogen receptor α (ERα) mediates 17β-estradiol (E2)-activated expression of HBO1.
    4. HBO1 promote MCM loading in vivo involves the stimulation of large-scale chromatin decondensation to allow access to the underlying DNA substrate.
      Title: Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.
    5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    7. results show that ING4 is a bivalent reader of the chromatin H3K4me3 modification and suggest a mechanism for enhanced targeting of the HBO1 complex to specific chromatin sites
      Title: The dimeric structure and the bivalent recognition of H3K4me3 by the tumor suppressor ING4 suggests a mechanism for enhanced targeting of the HBO1 complex to chromatin.
    8. H4 acetylation at origins by HBO1 is critical for DNA replication licensing.
      Title: HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.
    9. Immunohistochemistry for Hbo1 in 11 primary human tumor types revealed strong Hbo1 protein expression in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder.
      Title: Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers.
    10. Overexpression of MYST2 is associated with breast cancer.
      Title: Genetic alterations and oncogenic pathways associated with breast cancer subtypes.
    Submit: New GeneRIF Correction See all (19)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysines (K264, K266, K273) in the carboxy-terminus of integrase PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O95251 P10275 AR    HPRD  PubMed  
    O95251 P54259 ATN1    HPRD  PubMed  
    O95251 Q99728 BARD1    HPRD  PubMed  
    O95251 Q9H079 C15orf29    HPRD  PubMed  
    O95251 Q9H8G2 CAAP1    HPRD  PubMed  
    O95251 NDP52 CALCOCO2    HPRD  PubMed  
    O95251 Q9HC52 CBX8    HPRD  PubMed  
    O95251 Q9UQ88 CDK11A    HPRD  PubMed  
    O95251 P21127 CDK11B    HPRD  PubMed  
    O95251 Q8NHQ1 CEP70    HPRD  PubMed  
    O95251 Q96FC9 DDX11    HPRD  PubMed  
    O95251 Q92997 DVL3    HPRD  PubMed  
    O95251 Q96ED9 HOOK2    HPRD  PubMed  
    O95251 Q9UNL4 ING4    HPRD  PubMed  
    O95251 Q8WZ19 KCTD13    HPRD  PubMed  
    O95251 Q9P2H0 KIAA1377    HPRD  PubMed  
    O95251 P49736 MCM2    HPRD  PubMed  
    O95251 KIAA0980 protein NINL    HPRD  PubMed  
    O95251 Q13415 ORC1    HPRD  PubMed  
    O95251 Q9BY11 PACSIN1    HPRD  PubMed  
    O95251 P06746 POLB    HPRD  PubMed  
    O95251 Q08752 PPID    HPRD  PubMed  
    O95251 O15211 RGL2    HPRD  PubMed  
    O95251 P46783 RPS10    HPRD  PubMed  
    O95251 P21673 SAT1    HPRD  PubMed  
    O95251 Q99719 SEPT5    HPRD  PubMed  
    O95251 O95295 SNAPIN    HPRD  PubMed  
    O95251 P08670 VIM    HPRD  PubMed  
    O95251 Q9C0J8 WDR33    HPRD  PubMed  
    O95251 Q8NAP8 ZBTB8B    HPRD  PubMed  
    O95251 P49910 ZNF165    HPRD  PubMed  
    BioGRID:116315 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:116315 BioGRID:108156 ATN1    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:107056 BARD1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116315 BioGRID:122873 C15orf29    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:122971 CAAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:115535 CALCOCO2    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:121487 CBX8    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:107426 CDC6    BioGRID  PubMed Biochemical Activity 
    BioGRID:116315 BioGRID:107421 CDK11B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:116315 BioGRID:123555 CDT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116315 BioGRID:123234 CEP70    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:107838 CSNK1E    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:108028 DDX11    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:108190 DVL3    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:108118 DYNC1I1    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:119246 GMNN    BioGRID  PubMed Biochemical Activity 
    BioGRID:116315 BioGRID:114480 HAP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116315 BioGRID:113946 HIST1H3A    BioGRID  PubMed Biochemical Activity 
    BioGRID:116315 BioGRID:113955 HIST1H4A    BioGRID  PubMed Biochemical Activity 
    BioGRID:116315 BioGRID:113934 HIST2H2AC    BioGRID  PubMed Biochemical Activity 
    BioGRID:116315 BioGRID:118957 HOOK2    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:109314 HTT    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:119331 ING4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116315 BioGRID:124016 ING5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116315 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116315 BioGRID:129001 KCTD13    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:110339 MCM2    BioGRID  PubMed Biochemical Activity 
    BioGRID:116315 BioGRID:122280 MEAF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116315 BioGRID:116630 NINL    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:111040 ORC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:116315 BioGRID:111041 ORC2    BioGRID  PubMed Biochemical Activity 
    BioGRID:116315 BioGRID:119018 PACSIN1    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:116924 PHF15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116315 BioGRID:115113 PHF16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116315 BioGRID:123029 PHF17    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116315 BioGRID:111419 POLB    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:111477 PPID    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:111801 RGL2    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:112118 RPS10    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:112210 SAT1    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:111414 SEPT5    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:117101 SNAPIN    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116315 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116315 BioGRID:113272 VIM    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:120620 WDR33    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:575543 ZBTB8A    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:113511 ZNF165    BioGRID  PubMed Two-hybrid 
    BioGRID:116315 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity, transferring acyl groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H4-K12 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT histone H4-K16 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H4-K5 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H4-K8 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    histone acetyltransferase KAT7
    Names
    histone acetyltransferase KAT7
    MYST-2
    lysine acetyltransferase 7
    histone acetyltransferase MYST2
    MYST histone acetyltransferase 2
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
    histone acetyltransferase binding to ORC1
    NP_001186084.1
    NP_001186085.1
    NP_001186086.1
    NP_001186087.1
    NP_008998.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199155.1 → NP_001186084.1  histone acetyltransferase KAT7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC015795, AF217502, AK294836, DC306552
      Consensus CDS
      CCDS56035.1
      UniProtKB/TrEMBL
      B4DGY4
      UniProtKB/TrEMBL
      G5E9K7
      UniProtKB/Swiss-Prot
      O95251
      Related
      ENSP00000398961, OTTHUMP00000220717, ENST00000424009, OTTHUMT00000366037
      Conserved Domains (3) summary
      PLN03238
      Location:307 – 578
      Blast Score: 967
      PLN03238; probable histone acetyltransferase MYST; Provisional
      pfam01530
      Location:182 – 212
      Blast Score: 159
      zf-C2HC; Zinc finger, C2HC type
      pfam01853
      Location:360 – 543
      Blast Score: 863
      MOZ_SAS; MOZ/SAS family

    2. NM_001199156.1 → NP_001186085.1  histone acetyltransferase KAT7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC015795, AF217502, AK293976, DC306552
      Consensus CDS
      CCDS56037.1
      UniProtKB/TrEMBL
      B4DF85
      UniProtKB/TrEMBL
      E7ER15
      UniProtKB/Swiss-Prot
      O95251
      Related
      ENSP00000413415, OTTHUMP00000220714, ENST00000454930, OTTHUMT00000366033
      Conserved Domains (3) summary
      PLN03238
      Location:198 – 469
      Blast Score: 959
      PLN03238; probable histone acetyltransferase MYST; Provisional
      pfam01530
      Location:52 – 73
      Blast Score: 101
      zf-C2HC; Zinc finger, C2HC type
      pfam01853
      Location:251 – 434
      Blast Score: 853
      MOZ_SAS; MOZ/SAS family

    3. NM_001199157.1 → NP_001186086.1  histone acetyltransferase KAT7 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF217502, AK294014, DC306552
      Consensus CDS
      CCDS56036.1
      UniProtKB/Swiss-Prot
      O95251
      Related
      ENSP00000424577, OTTHUMP00000220715, ENST00000509773, OTTHUMT00000366034
      Conserved Domains (3) summary
      PLN03238
      Location:227 – 498
      Blast Score: 960
      PLN03238; probable histone acetyltransferase MYST; Provisional
      pfam01530
      Location:113 – 132
      Blast Score: 99
      zf-C2HC; Zinc finger, C2HC type
      pfam01853
      Location:280 – 463
      Blast Score: 855
      MOZ_SAS; MOZ/SAS family

    4. NM_001199158.1 → NP_001186087.1  histone acetyltransferase KAT7 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF217502, AK294052, DC306552
      Consensus CDS
      CCDS56038.1
      UniProtKB/Swiss-Prot
      O95251
      Related
      ENSP00000423385, OTTHUMP00000220716, ENST00000510819, OTTHUMT00000366035
      Conserved Domains (3) summary
      PLN03238
      Location:168 – 439
      Blast Score: 955
      PLN03238; probable histone acetyltransferase MYST; Provisional
      pfam01530
      Location:52 – 73
      Blast Score: 100
      zf-C2HC; Zinc finger, C2HC type
      pfam01853
      Location:221 – 404
      Blast Score: 847
      MOZ_SAS; MOZ/SAS family

    5. NM_007067.4 → NP_008998.1  histone acetyltransferase KAT7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF217502, DC306552
      Consensus CDS
      CCDS11554.1
      UniProtKB/Swiss-Prot
      O95251
      Related
      ENSP00000259021, OTTHUMP00000220713, ENST00000259021, OTTHUMT00000366032
      Conserved Domains (3) summary
      PLN03238
      Location:337 – 608
      Blast Score: 969
      PLN03238; probable histone acetyltransferase MYST; Provisional
      pfam01530
      Location:182 – 212
      Blast Score: 159
      zf-C2HC; Zinc finger, C2HC type
      pfam01853
      Location:390 – 573
      Blast Score: 867
      MOZ_SAS; MOZ/SAS family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      47865981..47906458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      43230982..43271467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC015795.20 (135239..170861) None
    genomic AC027801.10 (46742..51506) None
    genomic CH471109.2 EAW94658.1
      EAW94659.1
      EAW94660.1
      EAW94661.1
    mRNA AF074606.1 AAC99368.1
    mRNA AF140360.1 AAD42348.1
    mRNA AF217502.1 AAL56649.1
    mRNA AK023890.1 BAG51236.1
    mRNA AK122932.1 BAG53804.1
    mRNA AK293976.1 BAG57346.1
    mRNA AK294014.1 BAG57375.1
    mRNA AK294052.1 BAG57401.1
    mRNA AK294367.1 BAG57629.1
    mRNA AK294602.1 BAG57789.1
    mRNA AK294836.1 BAG57945.1
    mRNA AK295914.1 BAG58702.1
    mRNA AK297212.1 BAH12525.1
    mRNA BC015485.1 None
    mRNA BC032640.2 AAH32640.1
    mRNA DC306552.1 None
    other-genetic DQ890883.2 ABM81809.1
    other-genetic DQ894037.2 ABM84963.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95251.1 GenPept UniProtKB/Swiss-Prot:O95251
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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