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Items: 1 to 20 of 219

1.

Identification of differential signaling cues in insulin/IGF1 signaling pathways in breast cancer

(Submitter supplied) Temproral networks of (phospho)-proteins are constructed and analyzed to infer differential interactions under insulin and IGF1 stimulation.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL21723
945 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE80233
ID:
200080233
2.

CCL19 as a Chemokine Risk Factor for Posttreatment Lyme Disease

(Submitter supplied) Approximately 10% to 20% of patients optimally treated for early Lyme disease develop persistent symptoms of unknown pathophysiology termed posttreatment Lyme disease syndrome (PTLDS). The objective of this study was to investigate associations between PTLDS and immune mediator levels during acute illness and at several time points following treatment. Seventy-six participants with physician-documented erythema migrans and 26 healthy controls with no history of Lyme disease were enrolled. more...
Organism:
synthetic construct; Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL18408
589 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE84479
ID:
200084479
3.

Evaluation of autoantibody signatures in meningioma patients using human proteome array

(Submitter supplied) Our objective was to identify the potential autoantibody markers in meningiomas using high-density human proteome arrays (~17,000 full-length recombinant human proteins). This study revealed the dysregulation of 489 and 104 proteins in grades I and II of meningioma, respectively, along with the enrichment of signalling pathways which play a major role in the manifestation of the disease. This study revealed the dysregulation of 489 and 104 proteins in grades I and II of meningioma, respectively, along with the enrichment of signalling pathways which play a major role in the manifestation of the disease. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL22059
30 Samples
Download data:
GEO (GPR)
Series
Accession:
GSE83507
ID:
200083507
4.

In vitro infection of Bovine monocytes with Mycoplasma bovis delays apoptosis and suppresses production of IFNγ and TNF-α but not IL-10

(Submitter supplied) Mycoplasma bovis is one of the major causative pathogens of the bovine respiratory complex disease that is characterized by enzootic pneumonia, mastitis, pleuritis and polyarthritis. M. bovis enters and colonizes the bovine respiratory epithelia through inhalation of aerosol from contaminated air. The nature of the interaction between M. bovis and bovine innate immune system is not well understood. more...
Organism:
Bos taurus
Type:
Protein profiling by protein array
Platform:
GPL17262
6 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE47743
ID:
200047743
5.

Identification of target antigens of CSF OCB-derived monoclonal antibodies

(Submitter supplied) The identification of target antigens recognized by monoclonal antibodies that have been derived from oligoclonal band IgG of CSF samples from multiple sclerosis patients.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL13669
8 Samples
Download data:
GEO (GPR, XLS)
Series
Accession:
GSE72789
ID:
200072789
6.

Insulin-Like Growth Factor Receptor 1 and Mammalian Target Of Rapamycin Blockade: Novel Mechanisms of Resistance and Synergistic Drug Combinations for Ewing Sarcoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platforms:
GPL21490 GPL21488 GPL21489
54 Samples
Download data:
GEO
Series
Accession:
GSE78124
ID:
200078124
7.

In vivo proteomic expression changes in EW5 Ewing sarcoma xenografts after IGF-1R and/or mTOR blockade

(Submitter supplied) Ewing Sarcoma is caused by a pathognomonic genomic translocation that places an N-terminal EWSR1 gene in approximation with one of several ETS genes (typically FLI1). This aberration, in turn, alters the transcriptional regulation of more than five hundred genes and perturbs a number of critical pathways that promote oncogenesis, cell growth, invasion, and metastasis. Among them, translocation-mediated up-regulation of the insulin-like growth factor receptor 1 (IGF-1R) and mammalian target of rapamycin (mTOR) are of particular importance since they work in concert to facilitate IGF-1R expression and ligand-induced activation, respectively, of proven importance in ES transformation. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL21490
17 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE78123
ID:
200078123
8.

In vitro proteomic expression changes in Ewing sarcoma cell lines after mTOR blockade

(Submitter supplied) Ewing Sarcoma is caused by a pathognomonic genomic translocation that places an N-terminal EWSR1 gene in approximation with one of several ETS genes (typically FLI1). This aberration, in turn, alters the transcriptional regulation of more than five hundred genes and perturbs a number of critical pathways that promote oncogenesis, cell growth, invasion, and metastasis. Among them, translocation-mediated up-regulation of the insulin-like growth factor receptor 1 (IGF-1R) and mammalian target of rapamycin (mTOR) are of particular importance since they work in concert to facilitate IGF-1R expression and ligand-induced activation, respectively, of proven importance in ES transformation. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL21489
13 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE78122
ID:
200078122
9.

In vitro proteomic expression changes in Ewing sarcoma cell lines after IGF-1R or IGF-1R/IR blockade

(Submitter supplied) Ewing Sarcoma is caused by a pathognomonic genomic translocation that places an N-terminal EWSR1 gene in approximation with one of several ETS genes (typically FLI1). This aberration, in turn, alters the transcriptional regulation of more than five hundred genes and perturbs a number of critical pathways that promote oncogenesis, cell growth, invasion, and metastasis. Among them, translocation-mediated up-regulation of the insulin-like growth factor receptor 1 (IGF-1R) and mammalian target of rapamycin (mTOR) are of particular importance since they work in concert to facilitate IGF-1R expression and ligand-induced activation, respectively, of proven importance in ES transformation. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL21488
24 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE78121
ID:
200078121
10.

Nucleic Acid Programmable Protein Arrays (NAPPA) Somatic p53 Mutations

(Submitter supplied) Purpose: Mutations in TP53 induce autoantibody immune responses in a subset of cancer patients, which have been proposed as biomarkers for early detection. Here, we investigate the association of p53 specific autoantibodies with multiple tumor subtypes and determine the association with p53 mutation status and epitope specificity. Experimental Design: IgG p53 autoantibodies (p53-AAb), were quantified in 412 serum saples using a programmable ELISA assay from patients with serous ovarian, pancreatic adenocarcinoma, and breast cancer. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL21446
123 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE77949
ID:
200077949
11.

IL-18 nAbs block deleterious inflammatory cytokines induced by acute β-AR stimulation in heart

(Submitter supplied) To directly test whether inhibition of IL-18 by IL-18 neutralizing monoclonal antibodies (IL-18 nAbs) is sufficient for blocking the inflammatory responses of heart caused by acute β-adrenergic insult, mice were subjected to intraperitoneal injection with rat IL-18 nAbs or IgG as a negative control 1hr after isoproterenol treatment.
Organism:
Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL20892
16 Samples
Download data:
GEO (TXT, XLSX)
Series
Accession:
GSE82034
ID:
200082034
12.

Epitope mapping of a monoclonal antibody directed against Neisserial Heparin Binding Antigen

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Neisseria meningitidis; Neisseria meningitidis serogroup B
Type:
Protein profiling by protein array
Platforms:
GPL21867 GPL21866
6 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE81379
ID:
200081379
13.

Epitope mapping of a monoclonal antibody directed against Neisserial Heparin Binding Antigen by protein microarray

(Submitter supplied) The aim of the study was to determine the epitope targeted by 31E10/E7 mouse monoclonal antibody (mAb). mAb 31E10/E7 was diluted at 1:2000 and incubated on a non-commercial Protein Microarray platform printed with NHBA specific recombinant protein fragments and full length NHBA of different variants.
Organism:
Neisseria meningitidis
Type:
Protein profiling by protein array
Platform:
GPL21867
3 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE81378
ID:
200081378
14.

Epitope mapping of a monoclonal antibody directed against Neisserial Heparin Binding Antigen by peptide microarray

(Submitter supplied) The aim of the study was to determine the epitope targeted by 31E10/E7 mouse monoclonal antibody (mAb) and the cross-reactivity to linear peptide epitopes of 10 different Neisserial Heparin Binding Antigen (NHBA) variants. mAb 31E10/E7 was diluted at 1:200 and incubated on a custom PepStar Peptide Microarray platform printed with 560 different peptides in three independent experiments.
Organism:
Neisseria meningitidis serogroup B; Neisseria meningitidis
Type:
Protein profiling by protein array
Platform:
GPL21866
3 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE81377
ID:
200081377
15.

Detection of Alzheimer’s Disease at Mild Cognitive Impairment and Disease Progression Using Autoantibodies as Blood-based Biomarkers

(Submitter supplied) Human serum samples from Alzheimer's disease driven mild cognitive impairment and non-diseased controls were probed onto human protein microarrays in order to identify differentially expressed autoantibody biomarkers that could be used as diagnostic indicators. Other neurodegenerative and non-neurodegenerative diseases were also used to help measure the specificity of the selected biomarkers.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL13669
236 Samples
Download data:
GEO (GPR, XLS)
Series
Accession:
GSE74763
ID:
200074763
16.

Locally Advanced Rectal Cancer - Radiation Response Prediction Study - Serum Proteins

(Submitter supplied) The study objective was to find new biomarkers of treatment response and adverse events in patients receiving neoadjuvant therapy for locally advanced rectal cancer. Patients received neoadjuvant chemotherapy (NACT) followed by chemoradiotherapy (CRT) and underwent treatment evaluation four weeks after CRT completion. Radical pelvic surgery was planned 2-4 weeks later. Patients were scored for treatment adverse events, according to Common Terminology Criteria for Adverse Events (CTCAE) version 3.0, throughout the neoadjuvant treatment course, including at NACT and CRT completion. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL19737
288 Samples
Download data:
GEO (R)
Series
Accession:
GSE65622
ID:
200065622
17.

Autoantibodies and nucleic acids skew complement consumption in systemic lupus erythematosus

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Bos taurus; Capra hircus; Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL20261
1700 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE69372
ID:
200069372
18.

Autoantibodies and nucleic acids skew complement consumption in systemic lupus erythematosus [IgM]

(Submitter supplied) Systemic lupus erythematosus is a chronic autoimmune disease with multifactorial ethiopathogenesis. The complement system is involved in both the early and late stages of disease development and organ damage. To better understand autoantibody mediated complement consumption the GAPAID consortium examined ex vivo immune complex formation on autoantigen arrays. We recruited patients with SLE (n=211), with other systemic autoimmune diseases (n=65) and non-autoimmune control subjects (n=149) in two rheumatology tertiary care centers. more...
Organism:
Capra hircus; Bos taurus; Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL20261
425 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE69371
ID:
200069371
19.

Autoantibodies and nucleic acids skew complement consumption in systemic lupus erythematosus [IgG]

(Submitter supplied) Systemic lupus erythematosus is a chronic autoimmune disease with multifactorial ethiopathogenesis. The complement system is involved in both the early and late stages of disease development and organ damage. To better understand autoantibody mediated complement consumption the GAPAID consortium examined ex vivo immune complex formation on autoantigen arrays. We recruited patients with SLE (n=211), with other systemic autoimmune diseases (n=65) and non-autoimmune control subjects (n=149) in two rheumatology tertiary care centers. more...
Organism:
Capra hircus; Homo sapiens; Bos taurus
Type:
Protein profiling by protein array
Platform:
GPL20261
425 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE69370
ID:
200069370
20.

Autoantibodies and nucleic acids skew complement consumption in systemic lupus erythematosus [C4]

(Submitter supplied) Systemic lupus erythematosus is a chronic autoimmune disease with multifactorial ethiopathogenesis. The complement system is involved in both the early and late stages of disease development and organ damage. To better understand autoantibody mediated complement consumption the GAPAID consortium examined ex vivo immune complex formation on autoantigen arrays. We recruited patients with SLE (n=211), with other systemic autoimmune diseases (n=65) and non-autoimmune control subjects (n=149) in two rheumatology tertiary care centers. more...
Organism:
Capra hircus; Homo sapiens; Bos taurus
Type:
Protein profiling by protein array
Platform:
GPL20261
425 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE69366
ID:
200069366
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