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Links from PubMed

Items: 3

1.

Muscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL11154
6 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE45505
ID:
200045505
2.

Muscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming II

(Submitter supplied) Previous investigations of the core gene regulatory circuitry that controls embryonic stem cell (ESC) pluripotency have largely focused on the roles of transcription, chromatin and non- coding RNA regulators. Alternative splicing (AS) represents a widely acting mode of gene regulation, yet its role in the regulation of ESC pluripotency and differentiation is poorly understood. Here, we identify the Muscleblind-like RNA binding proteins, MBNL1 and MBNL2, as conserved and direct negative regulators of a large program of AS events that are differentially regulated between ESCs and other cell types. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL13112
5 Samples
Download data:
GEO (TXT), SRA SRP019989
Series
Accession:
GSE45504
ID:
200045504
3.

Muscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming I

(Submitter supplied) Previous investigations of the core gene regulatory circuitry that controls embryonic stem cell (ESC) pluripotency have largely focused on the roles of transcription, chromatin and non- coding RNA regulators. Alternative splicing (AS) represents a widely acting mode of gene regulation, yet its role in the regulation of ESC pluripotency and differentiation is poorly understood. Here, we identify the Muscleblind-like RNA binding proteins, MBNL1 and MBNL2, as conserved and direct negative regulators of a large program of AS events that are differentially regulated between ESCs and other cell types. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
1 Sample
Download data:
GEO (TXT), SRA SRP019988
Series
Accession:
GSE45503
ID:
200045503
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Supplemental Content

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