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Items: 3

1.

Chip-chip from Z138 MCL cell line with SOX11 antibody

(Submitter supplied) To determine the role of SOX11 in aggressive lymphoid neoplasm, we first investigated direct target genes of this transcription factor using chromatin immunoprecipitation and DNA microarrays (ChIP-chip) in MCL cell lines. Analysis of the exact location of SOX11 binding elements showed that SOX11 interacts with DNA predominantly in the enhancer regions (in 40% of the enriched regions) and intron segments (in 33% of the enriched regions), suggesting that in these genes SOX11 may interact with the general transcriptional machinery and transcriptional co-regulators.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL15114
4 Samples
Download data:
GEO (PAIR, TXT)
Series
Accession:
GSE35021
ID:
200035021
2.

SOX11 Gene Expression Profiling

(Submitter supplied) The neural transcription factor SOX11 is overexpressed in aggressive lymphoid neoplasms mainly in mantle cell lymphoma (MCL), but its functional role in malignant B-cells is unknown. To identify target genes transcriptionally regulated by SOX11 in malignant lymphoid cells, we have used Gene Expression Profiling (GEP) after SOX11 silencing in MCL cell lines.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4801
Platform:
GPL570
4 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE34763
ID:
200034763
3.
Full record GDS4801

Neural transcription factor SOX11 depletion effect on mantle cell lymphoma cell line

Analysis of Z138 mantle cell lymphoma (MCL) cells depleted for the neural transcription factor SOX11. SOX11 is overexpressed in aggressive lymphoid neoplasms mainly in MCL. Results provide insight into the role of SOX11 in the pathogenesis of MCL.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE34763
4 Samples
Download data:
GEO (CEL)
DataSet
Accession:
GDS4801
ID:
4801
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