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    Role of microRNAs in compensatory b-cell mass expansion associated with pregnancy and obesity

    (Submitter supplied) We found that in rodents, b-cell mass expansion during pregnancy and obesity is associated with changes in the expression of a group of islet microRNAs. We were able to reproduce in isolated pancreatic islets the decrease of miR-338-3p level observed in gestation and obesity by activating the G-protein coupled estrogen receptor GPR30 and the GLP1 receptor. Blockade of miR-338-3p in b-cells using specific anti-miR molecules mimicked gene expression changes occurring during b-cell mass expansion and resulted in increased proliferation and improved survival both in vitro and in vivo. more...
    Organism:
    Rattus norvegicus
    Type:
    Expression profiling by array; Non-coding RNA profiling by array
    Platforms:
    GPL10906 GPL6247
    14 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE36067
    ID:
    200036067

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