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    Results: 3

    1.

    EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Mus musculus; Homo sapiens
    Type:
    Expression profiling by array
    Platforms:
    GPL570 GPL1261
    17 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE32905
    ID:
    200032905
    2.

    EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]

    (Submitter supplied) The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in vivo that transcription factors inducing epithelial-mesenchymal transition can drive the development of claudin-low tumors from differentiated mammary epithelial cells, by playing a dual role in cell transformation and dedifferentiation.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    5 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE32904
    ID:
    200032904
    3.

    EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human]

    (Submitter supplied) The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in vivo that transcription factors inducing epithelial-mesenchymal transition can drive the development of claudin-low tumors from differentiated mammary epithelial cells, by playing a dual role in cell transformation and dedifferentiation.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    12 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE32727
    ID:
    200032727

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