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    Results: 2

    1.

    miRNA measurements in wildtype and Eri1-deficient Th cells

    (Submitter supplied) Natural killer (NK) cells play a critical role in early host defense to infected and transformed cells. Here we show that mice deficient in Eri1, a conserved 3’-to-5’ exoribonuclease that represses RNA interference, have a cell-intrinsic defect in the homeostasis and terminal maturation of NK cells. Eri1–/– NK cells show delayed acquisition of Ly49 receptors in the bone marrow and a selective reduction in Ly49D and Ly49H activating receptors in the periphery. more...
    Organism:
    Homo sapiens; Caenorhabditis elegans; Drosophila melanogaster; Rattus norvegicus; Danio rerio; Gallus gallus; Mus musculus
    Type:
    Non-coding RNA profiling by array
    Platforms:
    GPL14557 GPL14558
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE32126
    ID:
    200032126
    2.

    Small RNA profiling of wildtype and Eri1-deficient mouse T cells

    (Submitter supplied) Natural killer (NK) cells play a critical role in early host defense to infected and transformed cells. Here we show that mice deficient in Eri1, a conserved 3’-to-5’ exoribonuclease that represses RNA interference, have a cell-intrinsic defect in NK cell development and maturation. Eri1–/– NK cells displayed delayed acquisition of Ly49 receptors in the bone marrow and a selective reduction in Ly49D and Ly49H activating receptors in the periphery. more...
    Organism:
    Mus musculus
    Type:
    Non-coding RNA profiling by high throughput sequencing
    Platform:
    GPL9185
    2 Samples
    Download data:
    GEO (BED, TXT), SRA SRP008477
    Series
    Accession:
    GSE31920
    ID:
    200031920

      Supplemental Content

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