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A unique regulatory phase of DNA methylation in the early mammalian embryo

(Submitter supplied) DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of global cytosine methylation at fertilization, followed by passive depletion that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and to date no base-resolution maps exist to support and refine it. Here, we generated genome-scale DNA methylation maps in mouse gametes and through post-implantation embryogenesis. more...
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL11002
76 Samples
Download data:
GEO (TXT), SRA SRP010119
Series
Accession:
GSE34864
ID:
200034864

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