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    A unique regulatory phase of DNA methylation in the early mammalian embryo

    (Submitter supplied) DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of global cytosine methylation at fertilization, followed by passive depletion that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and to date no base-resolution maps exist to support and refine it. Here, we generated genome-scale DNA methylation maps in mouse gametes and through post-implantation embryogenesis. more...
    Organism:
    Mus musculus
    Type:
    Methylation profiling by high throughput sequencing
    Platform:
    GPL11002
    76 Samples
    Download data:
    GEO (TXT), SRA SRP010119
    Series
    Accession:
    GSE34864
    ID:
    200034864

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