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Links from PubMed

Items: 3

1.

Systems approach identifies HIPK2 as a critical regulator of kidney tubulointerstitial fibrosis

(Submitter supplied) We used an integrated computational/experimental systems biology approach to identify upstream protein kinases that regulate gene expression changes in kidneys of HIV-1 transgenic mice (Tg26), which have significant tubulo-interstitial fibrosis (TIF) and glomerulosclerosis (GS). We identified the homeo-domain interacting protein kinase 2 (HIPK2) as a key regulator of TIF and GS. HIPK2 was upregulated in kidneys of Tg26 and patients with various kidney diseases. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4233 GDS4234
Platforms:
GPL1261 GPL6244
24 Samples
Download data:
GEO (CEL, CHP)
Series
Accession:
GSE35226
ID:
200035226
2.
Full record GDS4234

Transgenic model Tg26 of HIV-Associated Nephropathy: kidney cortex

Analysis of kidney cortices from HIV-1 transgenic, FVB/N males and females (Tg26). Tg26 models the renal pathologic changes observed in human disease and is used to study HIV-associated nephropathy (HIVAN) pathogenesis. Results provide insight into the molecular mechanisms underlying HIVAN.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE35226
12 Samples
Download data:
GEO (CEL, CHP)
3.
Full record GDS4233

Protein kinase HIPK2 overexpression effect on Human Embryonic Kidney cells

Analysis of HEK293 cells transfected with homeo-domain interacting protein kinase 2 (HIPK2) and HIPK2-DN mutant. HIPK2 mediates renal fibrosis in 3 mouse models of renal fibrosis (Tg26, UUO, folic-acidinduced renal fibrosis). Results provide further insight into role of HIPK2 in kidney fibrosis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL6244
Series:
GSE35226
12 Samples
Download data:
GEO (CEL, CHP)
Format
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Send to:

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Supplemental Content

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