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    Comparison of hepatic gene expression between short-term calorie restricted wild-type and Dgat1 deficient middle-aged female mice

    (Submitter supplied) Leanness is associated with increased lifespan and is linked to favorable metabolic conditions promoting life extension. We show here that deficiency of the lipid synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which reduces body fat in mice, promotes longevity. Female DGAT1-deficient mice were protected from age-related increases in body fat, non-adipose tissue triglycerides, and markers of inflammation in white adipose tissue. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    9 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE26267
    ID:
    200026267

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