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Beta-catenin Controls Metastasis in Braf-activated Pten-inactivated Melanomas

(Submitter supplied) Malignant melanoma is characterized by frequent metastasis, however specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating beta-catenin levels in a mouse model of melanoma that is based on melanocyte-specific Pten loss and BrafV600E mutation, we demonstrate that beta-catenin is a central mediator of melanoma metastasis to lymph node and lung. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6246 GPL6096
6 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE32907
ID:
200032907

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