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    Results: 2

    1.

    Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver

    (Submitter supplied) Sex-dependent pituitary growth hormone (GH) secretory patterns determine the sex-biased expression of >1,000 genes in mouse and rat liver, affecting lipid and drug metabolism, inflammation and disease. A fundamental biological question is how robust differential expression can be achieved for hundreds of sex-biased genes simply based on the GH input signal pattern: pulsatile GH stimulation in males vs. more...
    Organism:
    Mus musculus
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platform:
    GPL9250
    19 Samples
    Download data:
    GEO (BED), SRA SRP007992
    Series
    Accession:
    GSE31578
    ID:
    200031578
    2.

    Unbiased, Genome-wide in vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-specific Liver Gene Expression

    (Submitter supplied) We have used a simple and efficient method to identify condition-specific transcriptional regulatory sites in vivo to help elucidate the molecular basis of sex-differences in transcription, which are widespread in mammalian tissues and affect normal physiology, drug response, inflammation and disease. To systematically uncover transcriptional regulators responsible for these differences, we used DNase hypersensitivity analysis coupled with high-throughput sequencing to produce condition-specific maps of regulatory sites in male and female mouse liver, and for livers of male mice feminized by continuous infusion of growth hormone (GH). more...
    Organism:
    Mus musculus
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platform:
    GPL9250
    10 Samples
    Download data:
    GEO (TXT), SRA SRP002445
    Series
    Accession:
    GSE21777
    ID:
    200021777

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