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Global analysis reveals HDAC1 occupies active and inactive genes and core transcription factors in embryonic stem cells and trophoblast stem cells

(Submitter supplied) Epigenetic regulation of gene expression is important in maintaining self-renewal of embryonic stem (ES) cells and trophoblast stem (TS) cells. Histone deacetylases (HDACs) negatively control histone acetylation by removing covalent acetylation marks from histone tails. Because histone acetylation is a known mark for active transcription, HDACs presumably associate with inactive genes. Here, we used genome-wide chromatin immunoprecipitation to investigate targets of HDAC1 in ES cells and TS cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL1261 GPL5811
18 Samples
Download data:
GEO (BAR, CEL)
Series
Accession:
GSE26087
ID:
200026087

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