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    A genomic storm in critically injured humans

    (Submitter supplied) Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and show that the severe stress produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected “genomic storm.” In severe blunt trauma, the early leukocyte genomic response is consistent with simultaneously increased expression of genes involved in the systemic inflammatory, innate immune, and compensatory antiinflammatory responses, as well as in the suppression of genes involved in adaptive immunity. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    857 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE36809
    ID:
    200036809

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