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Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis

(Submitter supplied) Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo [1,2]. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress response genes were preferentially upregulated during infection in the absence of the E gene. In addition, genes involved in signal transduction, transcription, cell metabolism, immunoregulation, inflammation, apoptosis and cell cycle and differentiation were differentially regulated in cells infected with rSARS-CoV with or without the E gene. more...
Organism:
Homo sapiens; Chlorocebus aethiops
Type:
Expression profiling by array
Platform:
GPL570
33 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE30589
ID:
200030589

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