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    Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates

    (Submitter supplied) Here, we demonstrate that Nematostella vectensis, Ciona intestinalis, Apis mellifera, and B. mori, show two distinct populations of genes differentiated by gene-body CpG density. Genome-scale DNA methylation profiles for A. mellifera spermatozoa reveal CpG-poor genes are methylated in the germ line, as predicted by the depletion of CpGs. We find an evolutionarily conserved distinction between CpG-poor and -rich genes: the former are associated with basic biological processes, the latter with more specialized functions. more...
    Organism:
    Apis mellifera
    Type:
    Methylation profiling by high throughput sequencing
    Platform:
    GPL13725
    1 Sample
    Download data:
    GEO (BED, TXT), SRA SRP007214
    Series
    Accession:
    GSE29982
    ID:
    200029982

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