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    Results: 2

    1.

    Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

    (Submitter supplied) Recurrent somatic mutations in TET2 and in other genes that regulate the epigenetic state have been identified in patients with myeloid malignancies and in other cancers. However, the in vivo effects of Tet2 loss have not been delineated. We report here that Tet2 loss leads to increased stem-cell self-renewal and to progressive stem cell expansion. Consistent with human mutational data, Tet2 loss leads to myeloproliferation in vivo, notable for splenomegaly and monocytic proliferation. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS4287
    Platform:
    GPL1261
    14 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE27816
    ID:
    200027816
    2.
    Full record GDS4287

    Effect of Tet2 loss in bone marrow progenitors

    Analysis of sorted bone marrow progenitor populations (LSK, CMP, GMP) deficient in ten-eleven translocation 2 (TET2). Tet2 loss causes increased hematopoietic stem cell self-renewal and myeloid transformation. Results provide insight into the molecular mechanisms underlying myeloid malignancies.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 4 cell type, 2 genotype/variation sets
    Platform:
    GPL1261
    Series:
    GSE27816
    14 Samples
    Download data:
    GEO (CEL)

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