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    Variegated gene expression caused by cell-specific long-range DNA interactions

    (Submitter supplied) Mammalian genomes contain numerous DNA elements with potential transcription regulatory function but unknown target genes. We used transgenic, gain-of-function mice with an ectopic copy of the beta-globin locus control region (LCR) to better understand how regulatory elements dynamically search the genome for target genes. We find that the LCR samples a restricted nuclear sub-volume in which it forms preferential contacts with genes controlled by shared transcription factors. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array; Other
    Platforms:
    GPL4344 GPL1261
    10 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE24614
    ID:
    200024614

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