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    Results: 2

    1.

    Rapid transcription of arc/arg3.1 and other very fast immediate early genes in response to neuronal activity is mediated by a stalled RNA polymerase II mechanism

    (Submitter supplied) Transcription of immediate early genes (IEGs) in neurons is exquisitely sensitive to neuronal activity, but the mechanism underlying the earliest of these transcription events is largely unknown. Here we demonstrate that very fast IEGs (VF-IEGs) such as arc/arg3.1 are poised for rapid transcription by the stalling of RNA Polymerase II (Pol II) just downstream of the transcription start site. RNAi-depletion of two subunits of Negative Elongation Factor, a mediator of Pol II stalling, reduces the Pol II occupancy of the arc promoter and compromises the rapid induction of arc and other VF-IEGs. more...
    Organism:
    Rattus norvegicus
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platform:
    GPL10287
    1 Sample
    Download data:
    GEO (BED), SRA SRP002901
    Series
    Accession:
    GSE22878
    ID:
    200022878
    2.

    Neurotoxin tetrodotoxin TTX withdrawal induced neuronal activity: RNA Pol II is poised for rapid induction of arc and other neuronal VF-IEGs

    (Submitter supplied) Transcription of immediate early genes (IEGs) in neurons is exquisitely sensitive to neuronal activity, but the mechanism underlying the earliest of these transcription events is largely unknown. Here we demonstrate that very fast IEGs (VF-IEGs) such as arc/arg3.1 are poised for rapid transcription by the stalling of RNA Polymerase II (Pol II) just downstream of the transcription start site. RNAi-depletion of two subunits of a mediator of Pol II stalling, Negative Elongation Factor, reduces Pol II occupancy of the arc promoter and compromises rapid induction of arc and other VF-IEGs. more...
    Organism:
    Rattus norvegicus
    Type:
    Expression profiling by array
    Platform:
    GPL4135
    9 Samples
    Download data:
    GEO (TIFF, TXT)
    Series
    Accession:
    GSE22622
    ID:
    200022622

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