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    Results: 2

    1.

    Global gene expression responses to low doses of protons in a human 3-dimensional skin model

    (Submitter supplied) Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different, necessitating the direct study of low dose responses. Most such studies have utilized 2-dimensional culture systems, which may not fully represent responses in 3-dimensional tissues. To gain insight into low dose responses in tissue, we have profiled global gene expression in EPI-200, a 3-dimensional tissue model that imitates the structure and function of human epidermis, at 4, 16 and 24 hours after exposure to high (2.5 Gy) and low (0.1 Gy) doses of low LET protons. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6480
    27 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE20629
    ID:
    200020629
    2.

    Response of the EPI-200 human 3-D skin model to high and low doses of protons

    (Submitter supplied) Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different, necessitating the direct study of low dose responses. Most such studies have utilized 2-dimensional culture systems, which may not fully represent responses in 3-dimensional tissues. To gain insight into low dose responses in tissue, we have profiled global gene expression in EPI-200, a 3-dimensional tissue model from MatTek that imitates the structure and function of human epidermis, at 4, 16 and 24 hours after exposure to high (2.5 Gy) and low (0.1 Gy) doses of low LET protons.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6480
    27 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE16935
    ID:
    200016935

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