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    Results: 4

    1.

    Network Analysis of Skin Tumor Progression Identifies a Rewired Genetic Architecture Affecting Inflammation and Tumor Susceptibility (aCGH)

    (Submitter supplied) Background: Germline polymorphisms can influence gene expression networks in normal mammalian tissues and can affect disease susceptibility. We and others have shown that analysis of this genetic architecture can identify single genes and whole pathways that influence complex traits including inflammation and cancer susceptibility. Whether germline variants affect gene expression in tumors which have undergone somatic alterations, and the extent to which these variants influence tumor progression, is unknown. more...
    Organism:
    Mus musculus
    Type:
    Genome variation profiling by genome tiling array
    Platform:
    GPL11355
    62 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE26273
    ID:
    200026273
    2.

    Inflammation and tumor susceptibility in skin cancer

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Mus musculus; Mus spretus; Mus musculus x Mus spretus
    Type:
    Expression profiling by array; Genome variation profiling by genome tiling array
    Platforms:
    GPL1261 GPL11355
    273 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE21264
    ID:
    200021264
    3.

    Network Analysis of Skin Tumor Progression Identifies a Rewired Genetic Architecture Affecting Inflammation and Tumor Susceptibility (papillomas)

    (Submitter supplied) Germline polymorphisms influence gene expression networks in normal mammalian tissues. Analysis of this genetic architecture can identify single genes and whole pathways that influence to complex traits including inflammation and cancer susceptibility. Changes in the genetic architecture during the development of benign and malignant tumours have not been investigated. Here, we document major changes in germline control of gene expression during skin tumour development as a consequence of cell selection, somatic genetic events, and changes in tumour microenvironment. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    68 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE21263
    ID:
    200021263
    4.

    Network Analysis of Skin Tumor Progression Identifies a Rewired Genetic Architecture Affecting Inflammation and Tumor Susceptibility (carcinomas)

    (Submitter supplied) Germline polymorphisms influence gene expression networks in normal mammalian tissues. Analysis of this genetic architecture can identify single genes and whole pathways that influence to complex traits including inflammation and cancer susceptibility. Changes in the genetic architecture during the development of benign and malignant tumours have not been investigated. Here, we document major changes in germline control of gene expression during skin tumour development as a consequence of cell selection, somatic genetic events, and changes in tumour microenvironment. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    60 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE21247
    ID:
    200021247

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