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    Specific functions for ERK/MAPK signaling during PNS development

    (Submitter supplied) We have established functions of the stimulus dependent MAPKs, ERK1/2 and ERK5 in DRG, motor neuron, and Schwann cell development. Surprisingly, many aspects of early DRG and motor neuron development were found to be ERK1/2 independent and Erk5 deletion had no obvious effect on embryonic PNS. In contrast, Erk1/2 deletion in developing neural crest resulted in peripheral nerves that were devoid of Schwann cell progenitors, and deletion of Erk1/2 in Schwann cell precursors caused disrupted differentiation and marked hypomyelination of axons. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6885
    8 Samples
    Download data:
    GEO (CSV)
    Series
    Accession:
    GSE24730
    ID:
    200024730

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