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    Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing

    (Submitter supplied) Copy number variants (CNVs) are a major source of genetic variation in human health and disease. Previous studies have suggested replication stress, such as that caused by the polymerase inhibitor aphidicolin, as a causative factor in CNV formation, but existing data are technically limited in the quality of the comparisons which can be made to experimentally induced variants. Here we used 1M feature single-nucleotide polymorphism (SNP) arrays and mate-pair sequencing as high resolution methods for characterizing CNVs in a common set of samples, to compare both the properties of constitutional and induced CNVs as well as the utility of the two methods in an experimental setting. more...
    Organism:
    Homo sapiens
    Type:
    Genome variation profiling by SNP array
    Platform:
    GPL8882
    2 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE26121
    ID:
    200026121

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