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    The miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor

    (Submitter supplied) Throughout most of pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) transcriptional activity, while spontaneous labor is initiated/facilitated by a concerted series of biochemical events that activate inflammatory pathways and negatively impact PR function. In this study, we uncovered a new regulatory pathway whereby miRNAs serve as hormonally-modulated and conserved mediators of contraction-associated genes in the pregnant uterus from mouse to human. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6887
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE25017
    ID:
    200025017

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