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L1 retrotransposition in neurons is mediated by MeCP2

(Submitter supplied) L1 retrotransposons are active elements in the genome, capable of mobilization in neuronal progenitor cells. Previously, we showed that chromatin remodeling during neuronal differentiation allows for a transient stimulation of L1 transcription. The activity of L1 retrotransposons during brain development can impact gene expression and neuronal function. Here we show that L1 neuronal retrotransposition in rodents is increased in the absence of MeCP2, a protein involved in global methylation and human neurodevelopmental diseases. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
21 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE21037
ID:
200021037

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