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    RNA Expression Profiling of Lung Tissue Identifies Mutually Distinct Molecular Signatures in PAH and PH Secondary to IPF

    (Submitter supplied) Idiopathic pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by pulmonary arteriolar remodeling, and is frequently associated with right heart failure. This study identifies significant novel biological changes in eight genes and several genetic pathways, that were likely to contribute to the pathogenesis of PAH. We also demonstrate that PAH and PH secondary to idiopathic pulmonary fibrosis (IPF) are characterized by distinct gene expression signatures, implying distinct pathophysiological mechanisms. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6480
    39 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE15197
    ID:
    200015197

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