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    Integrative Molecular Profiling in Leiomyosarcoma

    (Submitter supplied) Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We employed integrative molecular profiling to discover and characterize molecular subtypes of LMS. Gene expression profiling was performed on 51 LMS samples. Unsupervised clustering demonstrated 3 reproducible LMS clusters. Array comparative genomic hybridization (aCGH) was performed on 20 LMS samples and demonstrated that the molecular subtypes defined by gene-expression showed distinct genomic changes. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array; Genome variation profiling by array
    6 related Platforms
    75 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE17555
    ID:
    200017555

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