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    Results: 2

    1.

    Chromatin Poises miRNA- and Protein-coding Genes for Expression

    (Submitter supplied) Chromatin modifications have been implicated in regulation of gene expression. While association of certain modifications with expressed or silent genes has been established, it remains unclear how changes in chromatin environment relate to changes in gene expression. In this report, we used ChIP-Seq to analyze the genome-wide changes in chromatin modifications during activation of total human CD4+ T cells by T cell receptor (TCR) signaling. more...
    Organism:
    Homo sapiens
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platform:
    GPL9052
    10 Samples
    Download data:
    GEO (BED), SRA SRP001361
    Series
    Accession:
    GSE16657
    ID:
    200016657
    2.

    Dynamic regulation of nucleosome positioning in the human genome

    (Submitter supplied) The positioning of nucleosomes with respect to DNA plays an important role in regulating transcription. However, nucleosome mapping has been performed for only limited genomic regions in humans. We have generated genome-wide maps of nucleosome positions in both resting and activated human CD4+ T cells by direct sequencing of nucleosome ends using the Solexa high-throughput sequencing technique. Corresponding ChIP-Seq data are available in NCBI's Short Read Archive at ftp://ftp.ncbi.nlm.nih.gov/sra/Studies/SRP000/SRP000105 We find that nucleosome phasing relative to the transcription start sites (TSSs) is directly correlated to RNA polymerase II binding. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    4 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE10437
    ID:
    200010437

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