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Items: 3

1.

Distinctive Chromatin in Human Sperm Packages Genes that Guide Embryo Development: ChIP-chip

(Submitter supplied) As nucleosomes are widely replaced by protamine in mature human sperm, epigenetic contributions to embryo development appear limited. However, our genome-wide approaches find nucleosomes at low levels genome-wide, but also significantly enriched at imprinted gene clusters, miRNA clusters, HOX gene clusters, and the promoters of other developmental transcription and signaling factors. Developmental promoters were often DNA hypomethylated, and bore histone modifications localized to discrete locations: H3K4me2 is enriched at certain developmental promoters, whereas large blocks of H3K4me3 localize to a subset of developmental promoters, regions in HOX loci, certain non-coding RNAs, and generally to paternally-expressed imprinted loci. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array; Methylation profiling by genome tiling array
Platforms:
GPL4124 GPL4125
36 Samples
Download data:
GEO (TXT, XLS, ZIP)
Series
Accession:
GSE15701
ID:
200015701
2.

Distinctive Chromatin in Human Sperm Packages Genes that Guide Embryo Development: ChIP-seq

(Submitter supplied) As nucleosomes are widely replaced by protamine in mature human sperm, epigenetic contributions to embryo development appear limited. However, our genome-wide approaches find nucleosomes at low levels genome-wide, but also significantly enriched at imprinted gene clusters, miRNA clusters, HOX gene clusters, and the promoters of other developmental transcription and signaling factors. Developmental promoters were often DNA hypomethylated, and bore histone modifications localized to discrete locations: H3K4me2 is enriched at certain developmental promoters, whereas large blocks of H3K4me3 localize to a subset of developmental promoters, regions in HOX loci, certain non-coding RNAs, and generally to paternally-expressed imprinted loci. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9052
26 Samples
Download data:
GEO (TXT), SRA SRP001009
Series
Accession:
GSE15690
ID:
200015690
3.

Distinctive Chromatin in Human Sperm Packages Genes that Guide Embryo Development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Genome binding/occupancy profiling by genome tiling array; Methylation profiling by genome tiling array
Platforms:
GPL4125 GPL9052 GPL4124
62 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE15594
ID:
200015594
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