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    A synthetic gene-metabolic circuit preferentially increased fatty acid metabolism in human hepatocytes

    (Submitter supplied) Obesity is becoming increasingly widespread in developed countries, and is often associated with heart diseases and diabetes. Elevated levels of plasma free fatty acids are a biochemical hallmark of obesity. Unlike plants and bacteria, mammals cannot utilize fatty acids to generate glucose because of the lack of glyoxylate shunt enzymes. Instead, fatty acids are used for energy storage, and their utilization is regulated at multiple levels ranging from hormonal to metabolic ensuring that glucose is preferentially oxidized before fatty acids. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL571
    4 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE5903
    ID:
    200005903

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