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    Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster.

    (Submitter supplied) Cis-natural antisense transcripts (cis-NATs) have been speculated to be substrates for endogenous RNA interference (RNAi), but little experimental evidence for such a pathway in animals has been reported. Analysis of massive Drosophila melanogaster small RNA data sets now reveals that endogenous small interfering RNAs (siRNAs) are produced via bidirectional transcription. >100 cis-NATs with overlapping 3' exons generate 21-nt, Dicer-2 (Dcr-2)­dependent, 3'-end modified siRNAs. more...
    Organism:
    Drosophila melanogaster
    Type:
    Expression profiling by array
    Platform:
    GPL1322
    2 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE11370
    ID:
    200011370

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