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Items: 4

1.

Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen

(Submitter supplied) Background: Estrogen receptor positive (ER+) breast cancers (BC) are heterogeneous with regard to their clinical behavior and response to therapies. The ER is currently the best predictor of response to the anti-estrogen agent tamoxifen, yet up to 30-40% of ER+BC will relapse despite tamoxifen treatment. New prognostic biomarkers and further biological understanding of tamoxifen resistance are required. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
77 Samples
Download data:
GEO (CEL, RDATA, TXT)
Series
Accession:
GSE9195
ID:
200009195
2.

Definition of clinically distinct molecular subtypes in estrogen receptor positive breast carcinomas using genomic grade

(Submitter supplied) Purpose: A number of microarray studies have reported distinct molecular profiles of breast cancers (BC): basal-like, ErbB2-like and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although the basal and the ErbB2 subtypes are repeatedly recognized, identification of estrogen receptor (ER)-positive subtypes has been inconsistent. Refinement of their molecular definition is therefore needed. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL96 GPL97 GPL570
741 Samples
Download data:
GEO (CEL, RDATA, TXT)
Series
Accession:
GSE6532
ID:
200006532
3.

breast cancer / tamoxifen monotherapy (microdissected tumor biopsies)

(Submitter supplied) dataset of 60 patients with ER-positive primary breast cancer and treated with tamoxifen monotherapy for 5 years. Data were generated from LCMed cancer cells. Sample_keyword: breast cancer, tamoxifen, recurrence Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS807
Platform:
GPL1223
60 Samples
Download data:
GEO
Series
Accession:
GSE1378
ID:
200001378
4.
Full record GDS807

Estrogen positive breast cancer recurrence during tamoxifen therapy: microdissected tumor

Expression profiling of microdissected estrogen positive primary breast cancer tumors from 60 patients. Patients later treated with tamoxifen for 5 years, and tumors grouped according to whether cancer recurred. Results identify markers of disease-free survival that include HOXB13 and IL17BR.
Organism:
Homo sapiens
Type:
Expression profiling by array, log ratio, 2 disease state sets
Platform:
GPL1223
Series:
GSE1378
60 Samples
Download data:
GEO
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