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    RNA polymerase is poised for activation across the genome

    (Submitter supplied) Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA polymerase II (Pol II) to a promoter is necessary and sufficient for activation of gene. However, there are a few notable exceptions to this paradigm, including heat shock genes and several proto-oncogenes, whose expression is attenuated by regulated stalling of polymerase elongation within the promoter-proximal region. more...
    Organism:
    Drosophila melanogaster
    Type:
    Expression profiling by array; Genome binding/occupancy profiling by genome tiling array
    5 related Platforms
    29 Samples
    Download data:
    GEO (CEL, TIFF, TXT)
    Series
    Accession:
    GSE6714
    ID:
    200006714

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