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    Oncostatin M Regulation of Gene Expression in Breast Tumour Cells.

    (Submitter supplied) Oncostatin m (OSM) induces potent growth inhibitory and morphogenic responses in several different tumour cell types but the genetic events are not well understood. OSM can signal through two separate heterodimeric receptor complexes, gp130/LIFR╬▒ and gp130/OSMR╬▓. In this investigation we utilised cytokines, oncostatin M, interleukin-6 (IL-6) and leukaemia inhibitory factor (LIF) and LIF receptor antagonist, LIF-05, to help identify patterns of gene expression elicited by the different IL-6 receptor complexes in breast tumour cell line, T47D . more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL996
    28 Samples
    Download data:
    GEO (GPR, XLS)
    Series
    Accession:
    GSE4661
    ID:
    200004661

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