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    Results: 2

    1.

    Bis(2-chloroethoxy)methane-induced heart toxicity and recovery in male fisher rats

    (Submitter supplied) Specific gene changes after exposure to the heart toxin, bis(2-chloroethoxy)methane, were analyzed to elucidate critical pathways associated with recovery from heart toxicity. Bis(2-chloroethoxy)methane was administered to male F344/N rats at 0, 200, 400, or 600 mg/kg by dermal exposure for up to 16 days. Heart toxicity occurred at day 2 of exposure in all three regions of the heart (atrium, ventricle, interventricular septum) and was characterized by myofiber vacuolation, necrosis, mononuclear-cell infiltration, and atrial thrombosis. more...
    Organism:
    Rattus norvegicus
    Type:
    Expression profiling by array
    Dataset:
    GDS2566
    Platform:
    GPL890
    12 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE4254
    ID:
    200004254
    2.
    Full record GDS2566

    Bis(2-chloroethoxy)methane effect on hearts: time course

    Analysis of hearts exposed to the heart toxin bis(2-chloroethoxy)methane (CEM) for 2 or 5 days. Toxicity occurs at day 2 of CEM dosing, and recovery at day 5 despite continued dosing. Results provide insight into the molecular basis of heart toxicity and recovery during the exposure to CEM.
    Organism:
    Rattus norvegicus
    Type:
    Expression profiling by array, log2 ratio, 2 time sets
    Platform:
    GPL890
    Series:
    GSE4254
    12 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS2566
    ID:
    2566

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