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    Results: 2

    1.

    Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

    (Submitter supplied) In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-regulated expression of the vitamin D receptor and the vitamin D-1-hydroxylase genes, leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS2954
    Platform:
    GPL96
    50 Samples
    Download data:
    GEO (CEL, EXP)
    Series
    Accession:
    GSE8921
    ID:
    200008921
    2.
    Full record GDS2954

    Mycobacterium tuberculosis-derived lipopeptide effect on monocytes and dendritic cells: time course

    Analysis of monocytes (MOs) and MO-derived dendritic cells (DCs) for up to 24 hours following Mycobacterium tuberculosis-derived lipopeptide treatment. Toll-like receptor activation by bacterial lipopeptides reduced the viability of M. tuberculosis in MOs and macrophages but not MO-derived DCs.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 agent, 2 cell type, 15 individual, 5 time sets
    Platform:
    GPL96
    Series:
    GSE8921
    50 Samples
    Download data:
    GEO (CEL, EXP)
    DataSet
    Accession:
    GDS2954
    ID:
    2954

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