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Items: 2

1.

Omega-6 fatty acids, arachidonic acid (AA) activates PI3K signaling and induces gene expression in prostate cancer

(Submitter supplied) Essential fatty acids (FA) are not only energy-rich molecules; they are also an important component of the membrane bilayer and recently have been implicated in induction of fatty acid synthase (FAS) and other genes. Using gene chip analysis, we have found that arachidonic acid (AA), an omega-6 fatty acid, induced 11 genes that are regulated by NFkappaB. We verified gene induction by omega-6 fatty acids including COX2, IKBA, NFKB, GMCSF, IL1B, CXCL1, TNFA, IL6, LTA, IL8, PPARG, and ICAM1 using qRTPCR. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1736
Platform:
GPL96
8 Samples
Download data:
GEO (CEL, EXP)
Series
Accession:
GSE3737
ID:
200003737
2.
Full record GDS1736

Arachidonic acid effect on prostate cancer cells

Analysis of PC-3 prostate cancer cells incubated with arachidonic acid (AA). AA is an omega-6 fatty acid shown to induce cancer cell proliferation. Results suggest AA plays an important role in stimulation of growth-related genes and proliferation via phosphatidylinositol 3-kinase (PI3K) signaling.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL96
Series:
GSE3737
8 Samples
Download data:
GEO (CEL, EXP)
DataSet
Accession:
GDS1736
ID:
1736

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