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    Results: 2

    1.
    Full record GDS4476

    Parkin expression in parkin-deficient U87MG glioma cells

    Analysis of U87MG glioma cells stably expressing parkin or vector alone. Parkin expression is dramatically reduced in glioma cells. Parkin mutations are a major cause of parkinsonism. Results provide insight into tumor suppressor function of parkin in brain tumors.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 protocol sets
    Platform:
    GPL6244
    Series:
    GSE29494
    21 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS4476
    ID:
    4476
    2.

    Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival

    (Submitter supplied) Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivation in human malignant tumors. Here, we investigated a potential tumor suppressor role for parkin in gliomas. We found that parkin expression was dramatically reduced in glioma cells. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS4476
    Platform:
    GPL6244
    21 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE29494
    ID:
    200029494

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