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Links from GEO DataSets

Items: 5

1.
Full record GDS4421

Dendritic cell responses to proinflammatory TNF cytokine or pathogenic Trypanosoma brucei antigens

Analysis of dendritic cells (DCs) treated with TNFa cytokine or T. brucei-derived, variant-specific surface glycoproteins (AnTat1.1 mfVSG or MiTat1.5 sVSG). Results provide insight into the partial maturation signatures of the differentially stimulated DCs.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 5 agent sets
Platform:
GPL1261
Series:
GSE28231
5 Samples
Download data:
GEO (CEL)
DataSet
Accession:
GDS4421
ID:
4421
2.

Dendritic cell maturation by proinflammatory TNF or pathogenic Trypanosoma brucei antigens instruct similar T helper-2 cell responses in murine models of autoimmunity and asthma

(Submitter supplied) Background Dendritic cells (DC) represent the major cell type leading to polarized T helper (Th) cell responses in vivo. The current data indicate that DC maturation under inflammatory conditions or by helminth infections induce only incomplete DC maturation bearing a partially tolerogenic potential. Such semi-mature DC promoted a Th2 profile with increasing proportions of regulatory IL-10 producing T cells (Tr-1) upon restimulation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4421
Platform:
GPL1261
5 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE28231
ID:
200028231
3.

Human inflammatory dendritic cells induce Th17 differentiation

(Submitter supplied) Transcriptome analysis of five population of Antigen Presenting Cells: inflammatory macrophages, Inflammatory dendritic cells, Cd14+CD16- monocytes, CD14 dim Cd16+ monocytes and BDCA1+ Dendritic cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL11532
22 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE40484
ID:
200040484
4.

Microarray analysis of therapeutic (GM4) and non therapeutic (GM) NOD DC

(Submitter supplied) We have previously demonstrated that bone marrow-derived DC can prevent diabetes development and halt progression of insulitis in NOD mice, the mouse model of type 1 diabetes (T1D). The DC population that was most effective in this therapy had a mature phenotype, expressed high levels of costimulatory molecules and secreted low levels of IL-12p70. The protective DC therapy induced regulatory Th2 cells that shifted the dominant Th1 environment, present in NOD mice, to a mixed Th1/Th2 milieu. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4017
Platform:
GPL81
15 Samples
Download data:
GEO (CEL, CHP)
Series
Accession:
GSE15320
ID:
200015320
5.
Full record GDS4017

Activation of dendritic cells in NOD model of type 1 diabetes: time course

Analysis of therapeutic-GM4 and nontherapeutic-GM bone marrow-derived NOD dendritic cells (DC) up to 20 hrs after activation with LPS + IFN-gamma. The GM4 DC population is able to prevent diabetes in NOD mice. Results provide insight into the molecular basis of the therapeutic effect of GM4 DC.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 cell type, 3 time sets
Platform:
GPL81
Series:
GSE15320
15 Samples
Download data:
GEO (CEL, CHP)
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Supplemental Content

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