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    Results: 5

    1.
    Full record GDS4395

    External beam radiation therapy effect on prostate cancer patients: peripheral white blood cells

    Analysis of peripheral blood from men with non-metastatic prostate cancer (PC) on days 1, 7, 14, 21, 42 of external beam radiation therapy (EBRT), and at 30 days post-EBRT. Fatigue is a common side effect of EBRT. Results provide insight into molecular basis of fatigue in men with PC during EBRT.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 20 individual, 2 protocol, 8 time sets
    Platform:
    GPL570
    Series:
    GSE30174
    80 Samples
    Download data:
    GEO (CEL)
    2.

    Molecular-genetic correlates of fatigue in cancer patients receiving localized external beam radiation therapy

    (Submitter supplied) The etiology behind cancer-related fatigue (CRF) is currently unknown. The physiological mechanisms of CRF are based on limited evidence that genetic factors, energy expenditure, metabolism, aerobic capacity, and the individual's immune response to inflammation are responsible for the experience of CRF. Gene expression profiling using microarray analysis from white blood cells of men with non-metastatic prostate cancer shows significant, differential expression of 463 probesets during localized external beam radiation therapy (EBRT). more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS4395
    Platform:
    GPL570
    80 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE30174
    ID:
    200030174
    3.

    Expression data from RNAi SNCA treated human neuroblastoma cell line

    (Submitter supplied) The pre-synaptic protein α-synuclein is a key player in the pathogenesis of Parkinson's disease. Together with accumulation and missfolding of α-synuclein protofibrils serve as seed structures for the aggregation of numerous proteins in the cytoplasm of neuronal cells, the so-called Lewy bodies. Furthermore, missense mutations in the SNCA gene and gene multiplications lead to autosomal dominant forms of familiar PD. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    6 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE9807
    ID:
    200009807
    4.

    Molecular signatures of peripheral blood mononuclear cells following chronic IFN-alpha: Relationship of OAS2 with Depression and Fatigue

    (Submitter supplied) Interferon (IFN)-alpha causes high rates of depression and fatigue, and is used to investigate the impact of innate immune cytokines on brain and behavior. However, little is known about transcriptional profiles of circulating immune cells during chronic IFN-alpha administration. Accordingly, genome-wide transcriptional profiling was performed on peripheral blood mononuclear cells from 21 patients with chronic hepatitis C virus either awaiting IFN-alpha therapy (n=10) or after 12 weeks of IFN-alpha treatment (n=11). more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6947
    21 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE31187
    ID:
    200031187
    5.

    Analysis of striatal transcriptome in transgenic mice overexpressing human wild-type alpha-synuclein

    (Submitter supplied) Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson’s disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic neurons, more extensive yet regionally selective neurodegeneration is observed in other synucleinopathies. Furthermore, SNCA is ubiquitously expressed in neurons and numerous neuronal systems are dysfunctional in PD. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL339
    2 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE35723
    ID:
    200035723

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