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Links from GEO DataSets

Items: 19

1.
Full record GDS4377

CD43+/41+/235+ iPSC-derived progenitor cells with germ-line trisomy 21

Analysis of sorted CD43+/41+/235+ progenitors generated from trisomy 21 (T21) induced pluripotent stem cell (iPSC) lines. Down syndrome (DS, trisomy 21) affects many tissues, including blood, particularly during embryogenesis. Results provide insight into T21 effect on embryonic hematopoiesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6244
Series:
GSE35561
6 Samples
Download data:
GEO (CEL)
DataSet
Accession:
GDS4377
ID:
4377
2.

Expression data from trisomy 21 and euploid induced pluripotent stem cell hematopoietic progenitors

(Submitter supplied) We modeled human Trisomy 21 primitive hematopoiesis using induced pluripotent stem cells (iPSCs). Primitive multipotent progenitor populations generated from Trisomy 21 iPSCs showed normal proliferative capacity and megakaryocyte production, enhanced erythropoiesis and reduced myeloid development compared to euploid iPSCs.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4377
Platform:
GPL6244
6 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE35561
ID:
200035561
3.

Gene expression profiling in Vav-Etv2 KSL and Granulocyte hematopoietic cells

(Submitter supplied) Etv2 transgene was expressed from ROSA26 locus by removing floxed STOP cassette by Vav Cre transgene. KSL or Mac1+/Gr1+ cells were sorted from control or Vav-Etv2 bone marrow and compared for gene expression in duplicate. This study will reveal the effect of Etv2 transgene in adult hematopoietic cells. The effect of Etv2 overexpression in relevant mouse tissue will be important to understand its effect in comparison with in ES cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
8 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE36731
ID:
200036731
4.

Gene expression profiling in Tie-2-Etv2 endothelial and/or hematopoietic precursors

(Submitter supplied) Etv2 transgene was expressed from ROSA26 locus by removing floxed STOP cassette by Tie-2 Cre transgene. VE-Cad+/CD45= or VE-Cad+/CD45+ cells were sorted from control or tie-2-Etv2 E11.5 embryos (YS;yolk sac and Emb;embryo proper)and compared for gene expression in duplicate.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
16 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE36516
ID:
200036516
5.

Gene expression of 4, 5, and 6 days differentiated Flk1+ WT ES cells, and of 6 days differentiated Flk1+ Runx1-/- and Tal-1-/- ES cells

(Submitter supplied) In order to identify genes that are activated in differentiating WT ESCs, but are missing in Tal-1-/- and Runx1-/- ESCs, and which might be involved in the generation of definitive hematopoietic progenitors and their specification thereafter, we performed microarray analyses on purified Flk-1+ cells, differentiated from these ESCs for 4, 5, and 6 days “in vitro”.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
15 Samples
Download data:
GEO (CEL, CHP)
Series
Accession:
GSE46970
ID:
200046970
6.

The role of Ldb1 in hemangioblast development: genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL1261 GPL13112
16 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE43044
ID:
200043044
7.

The role of Ldb1 in hemangioblast development: genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis (Affymetrix)

(Submitter supplied) The first site exhibiting hematopoietic activity in mammalian development is the yolk sac blood island, which originates from the hemangioblast. Here we performed differentiation assays, as well as genome-wide molecular and functional studies in BL-CFCs to gain insight into the function of the essential Ldb1 factor in early primitive hematopoietic development. We show that the previously reported lack of yolk sac hematopoiesis and vascular development in Ldb1-/- mouse result from a decreased number of hemangioblasts and a block in their ability to differentiate into erythroid and endothelial progenitor cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE43042
ID:
200043042
8.

The role of Ldb1 in hemangioblast development: genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis (sequencing)

(Submitter supplied) The first site exhibiting hematopoietic activity in mammalian development is the yolk sac blood island, which originates from the hemangioblast. Here we performed differentiation assays, as well as genome-wide molecular and functional studies in BL-CFCs to gain insight into the function of the essential Ldb1 factor in early primitive hematopoietic development. We show that the previously reported lack of yolk sac hematopoiesis and vascular development in Ldb1-/- mouse result from a decreased number of hemangioblasts and a block in their ability to differentiate into erythroid and endothelial progenitor cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
10 Samples
Download data:
GEO (TXT), SRA SRP017620
Series
Accession:
GSE43041
ID:
200043041
9.

Developmental equivalence of epiblast stem cells (EpiSCs)

(Submitter supplied) Epiblast stem cells (EpiSCs) were derived from the epiblast or the ectoderm (epi/ect) of pre-gastrula stage to late-bud stage mouse embryos. To identify if the EpiSCs retain any original stage specific characteristics or which developmental stage of epi/ect they most closely related to, we performed microarray analysis to compare the gene expression profile of multiple EpiSC lines with that of epi/ect of 7 different stages.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
112 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE46227
ID:
200046227
10.

Critical role of SOX17 in the hematopoietic development from human embryonic stem cells

(Submitter supplied) Human embryonic stem cells (hESCs) are a powerful tool for modeling regenerative therapy. To search for the genes that promote hematopoietic development from human pluripotent stem cell, we overexpressed a list of hematopoietic regulator genes in human pluripotent stem cell-derived CD34+CD43- endothelial cells (ECs) enriched in hemogenic endothelium. Among genes tested, only SOX17, a gene encoding a transcription factor of the SOX family, promoted cell growth and supported expansion of CD34+CD43+CD45-/low cells expressing a hemogenic endothelial maker VE-cadherin. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array; Expression profiling by array
Platforms:
GPL14622 GPL6244
19 Samples
Download data:
GEO (CEL, TXT)
Series
Accession:
GSE38156
ID:
200038156
11.

ChIP-on-chip data from human ES cells-derived CD34+CD43+CD45low cells (hemogenic endothelium-like cells) overexpressing 3xFLAG-Sox17-ERT

(Submitter supplied) Overexpression of transcription factor Sox17 in human ES cells-derived endothelial cells enhances expansion of hemogenic endothelium-like cells.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL14622
1 Sample
Download data:
GEO (TXT)
Series
Accession:
GSE37528
ID:
200037528
12.

Expression data of human ES cells-derived CD34+CD43+CD45low cells (hemogenic endothelium-like cells) expanded upon overexpression of Sox17

(Submitter supplied) Overexpression of transcription factor Sox17 in human ES cells-derived endothelial cells and hematopoietic cells enhances expansion of hemogenic endothelium-like cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
18 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE37348
ID:
200037348
13.

Different propensity in hematopoietic differentiation potential among distinct human pluripotent stem cell lines

(Submitter supplied) Lineage-specific differentiation potential varies among different human pluripotent stem cell (hPSC) lines. A stem cell bank may advice researchers on which hPSCs exhibit the highest differentiation potential for a certain lineage. In this study, we aimed at characterizing the hematopoietic differentiation potential from 14 hESC/iPSC lines through the embryoid body (hEB) differentiation system.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
12 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE23091
ID:
200023091
14.

Genome-wide comparison of trisomy 21 iPSCs and derived isogenic disomy 21 iPSCs.

(Submitter supplied) Human trisomies can alter cellular phenotypes and produce congenital abnormalities such as Down Syndrome (DS). Here we have generated induced pluripotent stem cells (iPSCs) from DS fibroblasts, and introduced a TKNEO transgene into one copy of chromosome 21 by gene targeting. When selecting against TKNEO, spontaneous chromosome loss was the most common cause for survival, with a frequency of ~10-4, while point mutations, epigenetic silencing, and TKNEO deletions occurred at lower frequencies in this unbiased comparison of inactivating mutations. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
8 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE38931
ID:
200038931
15.

Global gene expression analysis of undifferentiated H1 hESC, and hEB cells differentiated with SF BVF2H conditions

(Submitter supplied) Global gene expression analysis of human embryoid body (hEB) differentiations during differentiation in serum free conditions in the presence of BMP4, VEGF, and FGF2 growth factors A total of 5 samples are analyzed. Each sample is taken at each time point. There is no replicate. H1_hESC_day0 sample is used as control to compare to other samples Keywords: Cell differentiation
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
5 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE12531
ID:
200012531
16.

Induced pluripotent stem cells can be generated in bulk culture

(Submitter supplied) Induced pluripotent stem cells (iPSCs) are usually clonally derived. The selection of fully reprogrammed cells generally involves picking of individual colonies with morphology similar to embryonic stem cells (ESCs). However, successfully reprogrammed cells are highly proliferative and escape from cellular senescence - it is therefore conceivable that they outgrow non-pluripotent and partially reprogrammed cells during culture expansion without the need of clonal selection. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
11 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE42807
ID:
200042807
17.

mRNA expression in Zfp36L2 knockout E14.5 fetal liver

(Submitter supplied) ZFP36L2, zinc finger protein 36, C3H type-like 2 (also known as Brf2, Erf2, Tis11D) is a member of the tristetraprolin (TTP; Zfp36) family of tandem CCCH zinc finger proteins that can bind to AU-rich elements (AREs) in the 3'-untranslated region of mRNAs, leading to their deadenylation and subsequent degradation. We have generated Zfp36l2 knockout mice. Knockout mice were born at the expected Mendelian frequency, but within several weeks of birth they died rather suddenly with pallor and frequent intestinal hemorrhage. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3574
Platform:
GPL1261
10 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE15146
ID:
200015146
18.
Full record GDS3574

Zfp36l2 deficiency effect on the fetal liver

Analysis of E14.5 fetal livers lacking Zfp36l2, a member of the tristetraprolin family of tandem CCCH zinc finger proteins. Knockout animals exhibit pancytopenia and decreased hematopoietic progenitor cells from fetal liver. Results provide insight into the role of Zfp36l2 in hematopoiesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE15146
10 Samples
Download data:
GEO (CEL)
DataSet
Accession:
GDS3574
ID:
3574
19.

Gene expression of human isogenic trisomy 21 induced pluripotent stem cells and derived neurons

(Submitter supplied) Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability, but the precise molecular mechanisms underlying impaired cognition remain unclear. Elucidation of these mechanisms has been hindered by the lack of a model system that contains full trisomy of chromosome 21 (Ts21) in a human genome that enables normal gene regulation. To overcome this limitation,we created Ts21-induced pluripotent stem cells (iPSCs) from two sets of Ts21 human fibroblasts. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
18 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE48611
ID:
200048611
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