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    Results: 17

    1.
    Full record GDS4369

    Normal colonic lamina propria macrophage and dendritic cell populations

    Analysis of sorted, steady-state colonic cells subdivided into 4 populations: 2 DC subsets and 2 MP subsets based on CD11c and F4/80 expression. DCs and MPs are important for immunological homeostasis in colon. Results provide insight into molecular characterization of colonic MP and DC populations.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 4 cell type sets
    Platform:
    GPL6246
    Series:
    GSE27859
    10 Samples
    Download data:
    GEO (CEL, CHP)
    2.

    Inflammation switches the differentiation program of Ly6Chi monocytes from anti-inflammatory macrophages to inflammatory dendritic cells in the colon

    (Submitter supplied) Dendritic cells (DCs) and macrophages (MPs) are important for immunological homeostasis in the colon. We found that F4/80hi CX3CR1hi (CD11b+CD103-) cells account for 80% of mouse colonic lamina propria (cLP) MHC-IIhi cells. Both CD11c+ and CD11c- cells within this population were identified as MPs based on multiple criteria, including a MP transcriptome revealed by microarray analysis. These MPs constitutively released high levels of IL-10 at least partially in response to the microbiota via an MyD88-independent mechanism. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS4369
    Platform:
    GPL6246
    10 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE27859
    ID:
    200027859
    3.

    Mouse lung CD103+ and CD11b-high dendritic cell (DC) subsets

    (Submitter supplied) Mouse lung CD11c+ dendritic cells are composed of 2 major DC subsets, the CD103+CD11b-low/intermediate DC (CD103+ DC) and the CD11b-highCD103- DC (CD11b-high DC). These 2 subsets are functionally distinct. Comparison of their functions showed CD103+ DC Microarray analysis was performed to compare the gene expression profiles of the 2 lung DC subsets in naïve mice.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    6 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE17322
    ID:
    200017322
    4.

    Ly6Chi monocytes in the inflamed colon give rise to pro-inflammatory effector cells and migratory antigen presenting cells.

    (Submitter supplied) We showed different function of monocyte derived cells in the lamina propria of the colon under steady state and inflammatory conditions. We used microarrays to detail the global programme of gene expression and identified distinct clusters of regulated genes during this process.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    8 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE42101
    ID:
    200042101
    5.

    Expression data from macrophages isolated from lupus NZB/W mouse kidneys prenephritic, nephritic or after complete remission.

    (Submitter supplied) Renal infiltration with mononuclear cells is associated with poor prognosis in SLE. A renal macrophage/dendritic cell signature is associated with onset of nephritis in NZB/W mice and immune modulating therapies can reverse this signature and the associated renal damage despite ongoing immune complex deposition. Our findings suggest that mononuclear phagocytes with an aberrant activation profile contribute to tissue damage in lupus nephritis by mediating both local inflammation and excessive tissue remodeling. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS4194
    Platform:
    GPL7546
    17 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE27045
    ID:
    200027045
    6.
    Full record GDS4194

    NZB/W model of systemic lupus erythematosus: renal macrophages

    Analysis of F4/80hi renal macrophages isolated at an early stage of lupus, during lupus nephritis, and after induction of remission. The infiltrating F4/80hi cells are associated with renal damage. Results provide insight into mechanisms by which F4/80hi macrophages contribute to lupus nephritis.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 3 tissue sets
    Platform:
    GPL7546
    Series:
    GSE27045
    17 Samples
    Download data:
    GEO (CEL)
    7.

    Transcriptional and functional profiling of human intestinal dendritic cells

    (Submitter supplied) This file contains gene microarray data from subsets of human intestinal dendritic cells, as defined by their expression of CD103 and Sirpa. This will allow for better understanding of human intestinal DC subsets in general and will facilitate translation from findings in the mouse.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6244
    11 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE50380
    ID:
    200050380
    8.

    Immunological Genome Project data Phase 1

    (Submitter supplied) Gene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplified and hybridized to Affymetrix 1.0 ST MuGene arrays. Protocols are rigorously standardized for all sorting and RNA preparation. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    681 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE15907
    ID:
    200015907
    9.

    Genome-wide expression study of the CD11b+ subsets of dermal myeloid cells and their migratory counterparts in the draining lymph node

    (Submitter supplied) Numerous CD11b+ myeloid cells are present within the dermis. They are very heterogeneous and can be divided in dermal DCs, tissue monocytes and tissue macrophages. At steady state, only CD11b+ DC migrate from the dermis to the skin draining lymph nodes whereas upon DNFB-induced inflammation, CD11b+ DC as well as dermal monocytes migrated to the lymph nodes. The objective of this study was to use gene expression profiling to rigorously identify the different subsets of dermal CD11b+ myeloid cells at steady state and upon inflammation and to characterize their functional potential.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    38 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE49358
    ID:
    200049358
    10.

    Transcriptome profile of human dermal macrophages and monocyte-derived macrophages

    (Submitter supplied) DC, monocyte and macrophage networks are evolutionarily conserved but the distinct subsets have been difficult to distinguish due to shared overlapping phenotypic markers between the cells. Using transcriptome microarray profiling of human and mouse mononuclear phagocyte subsets, we have distinguished human dermal DCs from monocyte-derived cells and macrophages.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6884
    11 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE60317
    ID:
    200060317
    11.

    Macrophage-restricted Interleukin-10 receptor-, but not IL-10 deficiency causes severe spontaneous colitis

    (Submitter supplied) Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and sensed by most hematopoietic cells. Genome wide association studies and experimental animal models point at a central role of the IL-10 axis in Inflammatory Bowel Diseases. Here we investigated the importance of intestinal macrophage production of IL-10 and their IL-10 exposure, as well as the existence of an IL-10-based autocrine regulatory loop in the gut. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    7 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE56444
    ID:
    200056444
    12.

    Gene expression of distinct lung dendritic cell subsets

    (Submitter supplied) Pulmonary dendritic cells are heterogenous cells comprise four distinct subsets including two conventional dendritic cell subsets, CD103+ and CD11bhiCD14lo cells, and two monocyte-derived dendritic cell subsets. Their functions in terms of migration and T cell activation are distinct, but genes regulating their features are to be determined. We used microarrays to identify a select set of genes that are expressed in conventinal dendritic cells and in monocyte-derived dendriti cells.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    12 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE64896
    ID:
    200064896
    13.

    Gene expression comparison among spleen dendritic cells, brain microglia, brain dendritic cells and bone marrow monocytes

    (Submitter supplied) To understand the functional relationship between brain dendritic cells (brain DCs) and other myeloid cells, we compared the gene expression profile of m/chDCs to that of bone marrow monocytes, brain microglia and classical spleen CD8+ and CD8- DCs. In order to obtain enough brain DCs for mRNA extraction, we expanded brain DCs with in vivo Flt3L treatment before purification.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    14 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE29949
    ID:
    200029949
    14.

    Initiation of an inflammatory response in resident intestinal lamina propria cells -use of a human organ culture model

    (Submitter supplied) Resident human lamina propria immune cells serve as powerful effectors in host defense. Molecular events associated with the initiation of an intestinal inflammatory response in these cells are largely unknown. Here, we aimed to characterize phenotypic and functional changes induced in these cells at the onset of intestinal inflammation using a human intestinal organ culture model. In this model, healthy human colonic mucosa was depleted of epithelial cells by EDTA treatment. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL10558
    8 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE56448
    ID:
    200056448
    15.

    Gene expression in cardiac macrophages

    (Submitter supplied) Three cardiac macrophage subsets and blood ly6chi monocytes were sorted to compare gene expression at steady state.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL11202
    16 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE53787
    ID:
    200053787
    16.

    Microarray analysis of splenic reservoir monocytes and their blood counterparts

    (Submitter supplied) A current paradigm states that monocytes circulate freely and patrol blood vessels, but differentiate irreversibly into dendritic cells or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The reservoir monocytes are relatively immotile, assemble in clusters in the cords of the subcapsular red pulp, and are distinct from macrophages and dendritic cells. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL7202
    8 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE14850
    ID:
    200014850
    17.

    Existence of conventional dendritic cells in Gallus gallus revealed by comparative gene expression profiling

    (Submitter supplied) The existence of conventional dendritic cells (cDCs) has not yet been demonstrated outside mammals. In this paper, we identified bona fide cDCs in chicken spleen. Comparative profiling of global and of immune response gene expression, morphology, and T cell activation properties show that cDCs and macrophages (MPs) exist as distinct mononuclear phagocytes in chicken, resembling their human and mouse cell counterparts. more...
    Organism:
    Gallus gallus
    Type:
    Expression profiling by array
    Platform:
    GPL18380
    15 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE55642
    ID:
    200055642

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