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Items: 11

1.
Full record GDS4231

Antiretroviral therapy effect on brain of patients with HIV-associated neurocognitive disorders

Analysis of postmortem brain of ART-treated, HIV-1-associated neurocognitive disorders (HAND) patients. ART reduces morbidity and mortality in HIV infection, but HAND persist despite treatment. Results provide insight into ART effectiveness in brain and into molecular signatures of HAND under ART.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 disease state sets
Platform:
GPL570
Series:
GSE28160
35 Samples
Download data:
GEO (CEL)
2.

Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-Associated Neurocognitive Disorders

(Submitter supplied) Antiretroviral therapy (ART) has reduced morbidity and mortality in HIV infection; however HIV-1-associated neurocognitive disorders (HAND) persist despite treatment. We used microarray analysis in post-mortem brain tissues to determine ART effectiveness in the brain and to identify molecular signatures of HAND under ART.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4231
Platform:
GPL570
35 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE28160
ID:
200028160
3.

Transcriptome analysis of primary monocytes from HIV+ patients with differential responses to therapy

(Submitter supplied) This study aimed at investigating the monocytic transcriptome distinction between patients with sustained virus suppression (BDL) and patients with virological failure during highly active antiretroviral therapy (HAART). This study provides the first transcriptomic distinctions in monocytes between viremic patients and BDLs on HAART. Our results reflected the outcome balanced between subversion of monocyte transcriptome by HIV and compensatory effect adapted by host cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
14 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE52900
ID:
200052900
4.

Toward a Better Understanding of Potential Roles of Astrocytes in HIV-1-associated Neurocognitive Disorders

(Submitter supplied) We present a microarray analysis of primary mouse astrocytes exposed to HIV-1 in culture. Results are compared with previous genomic studies of HIV-1 effect in human astrocytes and human and macaque brains.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data:
GEO (CEL, CHP)
Series
Accession:
GSE17383
ID:
200017383
5.

Genome wide mRNA expression correlates of viral control in CD4+T cells from HIV-1 infected individuals

(Submitter supplied) There is great interindividual variability in HIV-1 viral set point after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, the contribution of variable gene expression to viral control, and to relate it to genomic DNA polymorphism. RNA was extracted from purified CD4+ T-cells from 137 HIV-1 seroconverters, 16 elite controllers, and 3 healthy blood donors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
202 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE18233
ID:
200018233
6.

The National NeuroAIDS Tissue Consortium Brain Gene Array: Two types of HIV-associated neurocognitive impairment

(Submitter supplied) Finding the differences in gene expression in three regions of the brain, basal ganglia, white matter, and frontal cortex, in normal, HIV infected, HIV infected with neurocognitive impairment, and HIV infected with both neurocognitive impairment and encephalitis patients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4358
Platform:
GPL570
72 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE35864
ID:
200035864
7.
Full record GDS4358

Two types of HIV-associated neurocognitive impairment: brain regions

Analysis of basal ganglia, frontal cortex, and white matter from HIV patients with HIV-associated dementia (HAD) or HAD plus HIV encephalitis (HIVE). Results provide insight into molecular events of neurological impairment and inflammation associated with HIV infection in different brain regions.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 disease state, 3 tissue sets
Platform:
GPL570
Series:
GSE35864
72 Samples
Download data:
GEO (CEL)
8.

Evidence for Alteration of Gene Regulatory Networks through MicroRNAs of the HIV-Infected Brain

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by RT-PCR; Non-coding RNA profiling by array; Other
Platforms:
GPL570 GPL8979
11 Samples
Download data:
GEO (CEL, SDS, TXT)
Series
Accession:
GSE17491
ID:
200017491
9.

MicroRNAs in the HIV and Major Depressive Brain

(Submitter supplied) Micro-RNAs (miRNAs) are small, non-coding RNAs that regulate gene networks, helping to control cell function and phenotype. MiRNAs in the central nervous system (CNS) are considered to be involved in development, function, and homeostasis. Past genomic studies focused on messenger-RNA (mRNA) expression using large-scale hybridization-based arrays for elucidating gene expression in the brain during HIV-infection. more...
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR; Non-coding RNA profiling by array; Other
Platform:
GPL8979
3 Samples
Download data:
GEO (SDS, TXT)
Series
Accession:
GSE17486
ID:
200017486
10.

Gene Expression in Frontal Cortex in Major Depression and HIV

(Submitter supplied) Major depressive disorder (MDD) is a clinically defined entity with little understanding as to the underlying pathological substrate. Biologically, MDD is characterized by disruption of neurotransmitters, especially serotonin and noradrenaline, which are the main targets of antidepressants. We previously demonstrated significant reduction of glial cell number in the cingulate and dorsolateral prefrontal cortical regions. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
8 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE17440
ID:
200017440
11.

Transcriptome analysis of HIV-infected peripheral blood monocytes

(Submitter supplied) Immunologic dysfunction, mediated via monocyte activity, has been implicated in the development of HIV-associated neurocognitive disorder (HAND). We hypothesized that transcriptome changes in peripheral blood monocytes relate to neurocognitive functioning in HIV+ individuals, and that such alterations could be useful as biomarkers of worsening HAND. METHODS: mRNA was isolated from the monocytes of 86 HIV+ adults and analyzed with the Illumina HT-12 v4 Expression BeadChip. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
86 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE50011
ID:
200050011
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