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    Results: 18

    1.
    Full record GDS4168

    Chronic lymphocytic leukemia: peripheral blood B cells (HG-U133B)

    Analysis of peripheral blood B cells isolated from 41 untreated chronic lymphocytic leukemia (CLL) patients and 11 age-matched control subjects. B-cell CLL is the most common type of leukemia, mainly affecting adults. Results provide insight into molecular mechanisms underlying CLL pathogenesis.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 disease state sets
    Platform:
    GPL97
    Series:
    GSE22529
    52 Samples
    Download data:
    GEO (CEL)
    2.

    Gene expression profiles in CLL

    (Submitter supplied) Evaluation of differential expression between CLL patients in a chemoimmunotherapy trial with age-matched controls
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Datasets:
    GDS4167 GDS4168
    Platforms:
    GPL96 GPL97
    104 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE22529
    ID:
    200022529
    3.
    Full record GDS4167

    Chronic lymphocytic leukemia: peripheral blood B cells (HG-U133A)

    Analysis of peripheral blood B cells isolated from 41 untreated chronic lymphocytic leukemia (CLL) patients and 11 age-matched control subjects. B-cell CLL is the most common type of leukemia, mainly affecting adults. Results provide insight into molecular mechanisms underlying CLL pathogenesis.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 disease state sets
    Platform:
    GPL96
    Series:
    GSE22529
    52 Samples
    Download data:
    GEO (CEL)
    4.

    Cellular Origin and Pathophysiology of Chronic Lymphocytic Leukemia

    (Submitter supplied) The cellular origin of chronic lymphocytic leukemia (CLL) is debated. Transcriptome analysis of CLL and normal peripheral blood and splenic B cell subsets displayed highest similarity of CLL to mature CD5+ B cells. We identified a distinct CD5+CD27+ post-germinal center B cell subset, and revealed that immunoglobulin V gene mutated CLL are more similar to mutated CD5+ B cells, whereas unmutated CLL are more related to unmutated CD5+ B cells. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platforms:
    GPL570 GPL6244
    65 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE36907
    ID:
    200036907
    5.

    Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia

    (Submitter supplied) We conducted a genome-wide DNA methylation analysis in CD19+ B-cells from CLL patient and normal control samples using reduced representation bisulfite sequencing (RRBS). The methylation status of 1.8-2.3 million CpGs in the CLL genome was determined; about 45% of these CpGs were located in more than 23,000 CpG islands (CGIs). While global CpG methylation was similar between CLL and normal B-cells, 1764 gene promoters were identified as being differentially methylated between the two groups. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by high throughput sequencing
    Platform:
    GPL10999
    17 Samples
    Download data:
    GEO (BED), SRA SRP008815
    Series
    Accession:
    GSE32698
    ID:
    200032698
    6.

    Expression data from normal B cells and chronic lymphocytic leukemia B cells -- with/without treatment of Wnt3a

    (Submitter supplied) Wnt pathway is dysregulated in CLL-We characterized Wnt pathway gene expression in normal B and CLL-B cells and identified Wnt targets in normal B and CLL-B cells through this data set. In this dataset, we included normal B cells and CLL-B cells for Wnt pathway gene expression. This leads to the identification of 62 Wnt pathway components which are differnetially expressed between normal and CLl-B cells. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    221 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE31048
    ID:
    200031048
    7.

    Clinical Monoclonal B lymphocytosis versus Rai 0 Chronic Lymphocytic Leukemia: a comparison of the cellular, molecular, cytogenetic features and clinical course in a prospective multicenter study

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array; Non-coding RNA profiling by array
    Platforms:
    GPL8227 GPL6244
    310 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE40571
    ID:
    200040571
    8.

    Clinical Monoclonal B lymphocytosis versus Rai 0 Chronic Lymphocytic Leukemia: a comparison of the cellular, molecular, cytogenetic features and clinical course in a prospective multicenter study [mRNA]

    (Submitter supplied) Prospective series of 136 clinical monoclonal B lymphocytosis (cMBL) and 216 chronic lymphocytic leukemia (CLL) Rai 0 patients, were investigated in this study. While the distribution of CD38 and ZAP-70 positivity was similar, IGHV-mutated cases were more frequent among cMBL (P = 0.005). A Cox multivariate analysis on the whole patient cohort showed that cMBL condition was predictive of longer PFS, while CD38 expression and IGHV-unmutated status and CD38 expression correlated significantly with a shorter PFS in cMBL and Rai0-CLL, respectively. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6244
    160 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE40570
    ID:
    200040570
    9.

    Clinical Monoclonal B lymphocytosis versus Rai 0 Chronic Lymphocytic Leukemia: a comparison of the cellular, molecular, cytogenetic features and clinical course in a prospective multicenter study [miRNA]

    (Submitter supplied) Prospective series of 136 clinical monoclonal B lymphocytosis (cMBL) and 216 chronic lymphocytic leukemia (CLL) Rai 0 patients, were investigated in this study. While the distribution of CD38 and ZAP-70 positivity was similar, IGHV-mutated cases were more frequent among cMBL (P = 0.005). A Cox multivariate analysis on the whole patient cohort showed that cMBL condition was predictive of longer PFS, while CD38 expression and IGHV-unmutated status and CD38 expression correlated significantly with a shorter PFS in cMBL and Rai0-CLL, respectively. more...
    Organism:
    Homo sapiens
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL8227
    150 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE40533
    ID:
    200040533
    10.

    Analysis of chronic lymphocytic leukemia CLL cells and normal B cells

    (Submitter supplied) We have analyzed 2 normal B cells isolated from peripheral blood and 5 CLL specimens with affy 133A microarray for expression. We used microarrays to analyze gene expression in normal B cells and CLL cells.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL96
    7 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE18026
    ID:
    200018026
    11.

    Relevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array; Genome variation profiling by SNP array
    Platforms:
    GPL6244 GPL3718
    146 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE38618
    ID:
    200038618
    12.

    Relevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (SNP)

    (Submitter supplied) Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by chromosomal aberrations of prognostic significance. Recent studies showed that gain of chromosome 2p is a recurrent lesion in CLL. We investigated the 2p gain and its relationship with prognostic biomarkers in a prospective series of 287 early-stage CLLs (Binet A). The 2p gain was detected by FISH in 17 patients (6%) and further characterized by single nucleotide polymorphism-array. more...
    Organism:
    Homo sapiens
    Type:
    Genome variation profiling by SNP array
    Platform:
    GPL3718
    10 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE38613
    ID:
    200038613
    13.

    Relevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (expression)

    (Submitter supplied) Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by chromosomal aberrations of prognostic significance. Recent studies showed that gain of chromosome 2p is a recurrent lesion in CLL. We investigated the 2p gain and its relationship with prognostic biomarkers in a prospective series of 287 early-stage CLLs (Binet A). The 2p gain was detected by FISH in 17 patients (6%) and further characterized by single nucleotide polymorphism-array. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6244
    136 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE38611
    ID:
    200038611
    14.

    Expression data from WT DN3, TCF-1-deficient DN3 thymocytes, and T cell lymphomas in TCF-1-deficient animals.

    (Submitter supplied) TCF-1 is an HMG family transcription factor which is known to be critical for T cell development. We discovered that it has a unique role in suppressing malignant transformation of developing thymocytes at early stages. We identified ID2 and LEF-1 as key TCF-1 target genens in tumor suppression. We used microarrays to detect gene expression changes in WT and TCF-1 deficient DN3 thymocytes as well as T cell lymphoma cells developed in TCF-1 KO mice.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    12 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE33292
    ID:
    200033292
    15.

    Epigenomic profiling of glioblastoma stem cells

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by array
    4 related Platforms
    58 Samples
    Download data:
    GEO (CEL, WIG)
    Series
    Accession:
    GSE46016
    ID:
    200046016
    16.

    DNA methylation profiling of glioblastoma cancer stem cells

    (Submitter supplied) Glioblastoma (GBM) is thought to be driven by a sub-population of cancer stem cells (CSCs) that self-renew and recapitulate tumor heterogeneity, yet remain poorly understood. Here we present a comparative epigenomic analysis of GBM CSCs that reveals widespread activation of genes normally held in check by Polycomb repressors. These activated targets include a large set of developmental transcription factors (TFs) whose coordinated activation is unique to the CSCs. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL8490
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE46015
    ID:
    200046015
    17.

    Histone modification and TF ChIP-Seq for glioblastoma cell lines and neural stem cells

    (Submitter supplied) Glioblastoma (GBM) is thought to be driven by a sub-population of cancer stem cells (CSCs) that self-renew and recapitulate tumor heterogeneity, yet remain poorly understood. Here we present a comparative epigenomic analysis of GBM CSCs that reveals widespread activation of genes normally held in check by Polycomb repressors. These activated targets include a large set of developmental transcription factors (TFs) whose coordinated activation is unique to the CSCs. more...
    Organism:
    Homo sapiens
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platforms:
    GPL9115 GPL11154
    40 Samples
    Download data:
    GEO (WIG)
    Series
    Accession:
    GSE46014
    ID:
    200046014
    18.

    Expression profiling of glioblastoma cancer stem cells

    (Submitter supplied) Glioblastoma (GBM) is thought to be driven by a sub-population of cancer stem cells (CSCs) that self-renew and recapitulate tumor heterogeneity, yet remain poorly understood. Here we present a comparative epigenomic analysis of GBM CSCs that reveals widespread activation of genes normally held in check by Polycomb repressors. These activated targets include a large set of developmental transcription factors (TFs) whose coordinated activation is unique to the CSCs. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    12 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE45899
    ID:
    200045899

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