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    Results: 4

    1.
    Full record GDS4152

    Multiple sclerosis patients with high serum semaphorin4A levels: peripheral blood cells

    Analysis of peripheral blood from MS patients with high or low serum levels of transmembrane-type semaphorin Sema4A. MS patients with high Sema4A levels have more severe disabilities and are unresponsive to IFN-β treatment. Results provide insight into role of Sema4A in the pathogenesis of MS.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 disease state, 2 genotype/variation sets
    Platform:
    GPL570
    Series:
    GSE26484
    10 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS4152
    ID:
    4152
    2.

    Sema4A, a novel serum marker of multiple sclerosis, implicates Th17 pathology and efficacy of interferon-β.

    (Submitter supplied) Background: Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system and the leading cause of lasting neurological disabilities in young adults. Increasing evidence suggests that early treatment prevents the development of disability. However, there have been no reliable serum markers to assist the early diagnosis. In addition, interferon (IFN)-β, which is the major treatment for MS, is not always effective. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS4152
    Platform:
    GPL570
    10 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE26484
    ID:
    200026484
    3.

    Interferon beta-1a-induced changes in gene expression in PBMCs derived from CIS patients

    (Submitter supplied) IFNβ, an effective therapy against relapsing-remitting (RR) multiple sclerosis (MS) is naturally secreted during the innate immune response against viral pathogens. The objective of this study was to characterize the immunomodulatory mechanisms of IFNβ targeting innate immune response and their effects on DC-mediated regulation of T-cell differentiation. We found that IFNβ−1a in-vitro treatment of human monocyte-derived dendritic cells (DCs) induced the expression of TLR7 and the members of its downstream signaling pathway, including myeloid differentiation factor 88 (MyD88), IL-1R-associated kinase (IRAK)4, and TNF receptor-associated factor (TRAF)6, while it inhibited the expression of IL-1R. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    30 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE14386
    ID:
    200014386
    4.

    Transcriptional Activity in Lymph Nodes During the Initiation and Progression of Autoimmune Encephalomyelitis

    (Submitter supplied) NOD mice (8- to 13-wk-old) were bred and maintained at the La Trobe University Central Animal House (Bundoora, Melbourne, Australia). All experiments were conducted in accordance with the Australian code of practice for the care and use of animals for scientific purposes (National Health and Medical Research Council 1997), after approval by the La Trobe University Animal Ethics committee (Melbourne, Australia). more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL5032
    72 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE7461
    ID:
    200007461

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