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    Results: 8

    1.
    Full record GDS4123

    Isoflavone and 3,3’-diindolylmethane effect on C4-2B prostate cancer cells

    Analysis of C4-2B prostate cancer (PCa) cells treated with isoflavone (IsoF) and 3,3’- diindolylmethane (B-DIM) for up to 72 hours. IsoF and B-DIM inhibited the signal transductions in PCa signaling. Results provide insight into molecular mechanisms underlying PCa growth.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 3 agent, 4 time sets
    Platform:
    GPL570
    Series:
    GSE35324
    5 Samples
    Download data:
    GEO (CEL)
    2.

    Genome-wide analysis of gene expression in isoflavone and 3,3’-diindolylmethane treated C4-2B prostate cancer cells

    (Submitter supplied) Expression profiling of isoflavone and 3,3’-diindolylmethane treated C4-2B prostate cancer cells was conducted using Affymetrix Human Genome U133 Plus 2.0. Array
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS4123
    Platform:
    GPL570
    5 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE35324
    ID:
    200035324
    3.

    MicroRNA profiling in primary prostate cancer

    (Submitter supplied) Deregulated expression of miRNAs contributes to prostate cancer progression. This study is aimed to identify which miRNA(S) is (are) asociated with prostate cancer aggressiveness.
    Organism:
    Homo sapiens
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL14987
    2 Samples
    Download data:
    GEO (XLS)
    Series
    Accession:
    GSE34310
    ID:
    200034310
    4.

    Effects of prostate cancer cells on osteoblasts

    (Submitter supplied) Primary murine osteoblasts were isolated form the calvariae of newborn mice. 10 days after the addition of ascorbic acid (50 µg/ml) and ß-glycerophosphate (10 mM), cells were serum-starved over night and then incubated for 6 hours with condtioned medium of MDA-PCa2b cells or conditioned medium of PC-3 cells Keywords: expression profiling by array
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    2 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE17348
    ID:
    200017348
    5.

    A Characterization of Osteoblastic and Osteolytic Proteins in Prostate Cancer Bone Metastases

    (Submitter supplied) Our goal was to determine whether previously identified and novel proteins are associated with the osteoblastic or osteolytic response in clinical specimens of PCa bone metastases.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL15659
    14 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE41619
    ID:
    200041619
    6.

    Runx2 Transcriptome of Prostate Cancer Cells: Insights into Invasiveness and Bone Metastasis

    (Submitter supplied) Background: Prostate cancer (PCa) cells preferentially metastasize to bone at least in part by acquiring osteomimetic properties. Runx2, an osteoblast master transcription factor, is aberrantly expressed in PCa cells, and promotes their metastatic phenotype. The transcriptional programs regulated by Runx2 have been extensively studied during osteoblastogenesis, where it activates or represses target genes in a context-dependent manner. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6883
    16 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE24261
    ID:
    200024261
    7.

    Osteoblastic response in human bone marrow stromal cells

    (Submitter supplied) Our goal was to determine whether osteoblastic LuCaP 23.1 prostate cancer xenograft tumors can elicit an osteoblastic response at the gene expression level in human bone marrow stromal cells.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL15659
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE48907
    ID:
    200048907
    8.

    Amplification of RANK- and c-Met-mediated signaling promotes metastatic colonization

    (Submitter supplied) We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic niche through a forward feedback loop by inducing RANKL and c-Met expression and downstream signaling via upregulation of master regulator transcription factors regulating EMT (Twist1, Slug, Zeb1, Zeb2), stem cells (Sox2, Myc, Oct3/4 and Nanog), neuroendocrine cells (Sox 9, HIF-1α and FoxA2) and osteomimicry (c-Myc/Max, Sox2, Sox9, HIF1α and Runx2). more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    4 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE48432
    ID:
    200048432

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