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    Results: 10

    1.
    Full record GDS4047

    Chronic myelogenous leukemia CD34+CD38- cells response to histone deacetylase inhibitor analog and imatinib mesylate

    Analysis of sorted chronic myelogenous leukemia (CML) CD34+CD38- cells cultured with histone deacetylase inhibitor analog LBH589 (LBH) and/or BCR-ABL tyrosine kinase inhibitor imatinib mesylate (IM). Results provide insight into molecular mechanisms underlying treatment of CML with LBH and IM.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 4 agent sets
    Platform:
    GPL570
    Series:
    GSE20876
    12 Samples
    Download data:
    GEO (CEL)
    2.

    Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate

    (Submitter supplied) We investigated the ability of HDAC inhibitors (HDACi) to target CML stem cells. Treatment with HDACi combined with IM effectively induced apoptosis in quiescent CML progenitors resistant to elimination by IM alone, and eliminated CML stem cells capable of engrafting immunodeficient mice. In vivo administration of HDACi with IM markedly diminished LSC in a transgenic mouse model of CML. The interaction of IM and HDACi inhibited genes regulating hematopoietic stem cell maintenance and survival. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS4047
    Platform:
    GPL570
    12 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE20876
    ID:
    200020876
    3.

    Physiologic Hypoxia Promotes Maintenance of CML Stem Cells Despite Effective BCR−ABL1 Inhibition

    (Submitter supplied) ABL1 kinase inhibitors such as imatinib mesylate (IM) are effective in managing chronic myelogenous leukemia (CML) but incapable of eliminating leukemia stem cells (LSCs), suggesting that kinase−independent pathways support LSC survival. Given that the bone marrow hypoxic microenvironment supports hematopoietic stem cells, we investigated if hypoxia similarly contributes to LSC persistence. Importantly, we found that while BCR−ABL1 kinase remained effectively inhibited by IM under hypoxia, apoptosis became partially suppressed. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL10558
    24 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE48294
    ID:
    200048294
    4.

    The effect of IM and MSC treatment on gene expression in CML CD34+ cells

    (Submitter supplied) Tyrosine kinase inhibitors (TKI) are highly effective in treatment of chronic myeloid leukemia (CML) but do not eliminate leukemia stem cells (LSC), which remain a potential source of relapse. TKI treatment effectively inhibits BCR-ABL kinase activity in CML LSC, suggesting that additional kinase-independent mechanisms contribute to LSC preservation. We investigated whether signals from the bone marrow (BM) microenvironment protect CML LSC from TKI treatment. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS4756
    Platform:
    GPL6244
    12 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE43225
    ID:
    200043225
    5.
    Full record GDS4756

    Bone marrow microenvironment effect on imatinib-treated chronic myeloid leukemia CD34+ cells

    Analysis of CML cells treated with tyrosine kinase inhibitor (TKI) imatinib and BM mesenchymal stromal cells (MSCs). Coculture with MSCs protects the CML cells from TKI-mediated cell death and depletion. Results provide insight into microenvironmental protection of CML cells from TKI treatment.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 4 protocol, 2 tissue sets
    Platform:
    GPL6244
    Series:
    GSE43225
    12 Samples
    Download data:
    GEO (CEL)
    6.

    Chronic myelogenous leukemia hematopoietic stem cells

    (Submitter supplied) We show the molecular and functional characterization of a novel population of lineage-negative CD34-negative (Lin- CD34-) hematopoietic stem cells (HSCs) from chronic myelogenous leukemia (CML) patients at diagnosis. Molecular caryotyping and quantitative analysis of BCR/ABL transcript demonstrated that about one third of CD34- was leukemic. CML CD34- cells showed kinetic quiescence and limited clonogenic capacity. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL8300
    6 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE11675
    ID:
    200011675
    7.

    human leukemia cell line K562 offspring acquring imatinib resistance(K562-r) : Control vs. Drug treated

    (Submitter supplied) Transcriptional profiling of K562-r comparing control untreated human leukemia cells with human leukemia cells treated with AMN107 and ATO individually or combined.Four timepoints included are 3h,12h,24h,48h, covering the whole time window of K562-r cells responsing to the drug treatment.At the combination of 1.5uM ATO and 8uM AMN107, K562-r cells have the most significant coordinated effects (the apoptosis rate at 72h was 56.41% compared to 12.23% in ATO alone and 29.8% in AMN107 alone.). more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL11118
    17 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE24946
    ID:
    200024946
    8.

    Transcriptome profiling of fenretinide-treated and untreated CD34+ cells from 4 CML patients

    (Submitter supplied) Imatinib, as the first-line agent of chronic myeloid leukemia (CML), is ineffective in eradicating CML stem/progenitor cells, thus unable to prevent late relapse. Here we present data indicating that fenretinide preferentially targets CD34+ CML cells and enhances the efficacy of imatinib in CML. As tested by colony forming cell assays, both number and size of total colonies derived from CD34+ CML cells were significantly reduced by fenretinide, and by combining fenretinide with imatinib. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    8 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE17480
    ID:
    200017480
    9.

    Identification of targets regulated by SELP in HSC

    (Submitter supplied) To understand the underlying mechanism by which Alox15 gene is required by HSCs, we performed a comparative DNA microarray analysis using total RNA isolated from wild type Lin-Sca-1+c-Kit+, SELP-/- Lin-Sca-1+c-Kit+. The result was validated by quantitative real-time PCR analysis of wild type Lin-Sca-1+c-Kit+ and SELP-/- Lin-Sca-1+c-Kit+. Cancer stem cells are responsible for the initiation and maintenance of some types of cancer, and few effective target genes in these stem cells have been identified. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    6 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE57459
    ID:
    200057459
    10.

    Treatment of primary acute myelogenous leukemia (AML) specimens with parthenolide (PTL)

    (Submitter supplied) The effects of 7.5 micromolar parthenolide (PTL) were assessed on primary CD34+ acute myelogenous leukemia specimens obtained from 12 patients. Keywords: drug response, gene expression search agent
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    24 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE7538
    ID:
    200007538

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