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    Results: 10

    1.
    Full record GDS3848

    HMEC-1 endothelial cell line response to infection by Rickettsia prowazekii

    Analysis of endothelial cells infected by R. prowazekii strains (Erus, Evir, Rp22) of varying virulence. Virulent R. prowazekii causes epidemic typhus and avirulent strains can revert to virulence. Results provide insight into the molecular basis of virulence and adaptive mutation in R. prowazekii.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 4 strain sets
    Platform:
    GPL4133
    Series:
    GSE16123
    16 Samples
    Download data:
    GEO (TXT)
    2.

    Multiomics study to identify virulence factors of Rickettsia prowazekii revealed its adaptive mutation capabilities

    (Submitter supplied) We identified four virulence phenotypes of Rickettsia prowazekii (the deadly agent of epidemic typhus) that are associated with the upregulation of antiapoptotic genes (virulent strain) or the Interferon I pathway (avirulent). Transcriptional and proteomic analyses of R. prowazekii linked surface protein expression and methylation with virulence. By sequencing a virulent strain and using comparative genomics, we found hotspots of mutations in homopolymeric tracts of poly(A) and poly(T) that lead to gene split and inactivation and explain the loss of virulence in the vaccine strain. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS3848
    Platform:
    GPL4133
    16 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE16123
    ID:
    200016123
    3.

    Multiomics study to identify virulence factors of Rickettsia prowazekii revealed its adaptive mutation capabilities

    (Submitter supplied) We identified four virulence phenotypes of Rickettsia prowazekii (the deadly agent of epidemic typhus) that are associated with the upregulation of antiapoptotic genes (virulent strain) or the Interferon I pathway (avirulent). Transcriptional and proteomic analyses of R. prowazekii linked surface protein expression and methylation with virulence. By sequencing a virulent strain and using comparative genomics, we found hotspots of mutations in homopolymeric tracts of poly(A) and poly(T) that lead to gene split and inactivation and explain the loss of virulence in the vaccine strain. more...
    Organism:
    Rickettsia prowazekii str. Rp22; Rickettsia prowazekii str. Madrid E; Rickettsia prowazekii
    Type:
    Expression profiling by array
    Platform:
    GPL8427
    3 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE15630
    ID:
    200015630
    4.

    Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa

    (Submitter supplied) Comparison of gene expression between the virulent Rickettsia rickettsii R strain and avirulent Rickettsia rickettsii Iowa. Keywords: virulent vs avirulent
    Organism:
    Coxiella burnetii RSA 493; Granulibacter bethesdensis; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydophila caviae GPIC; Staphylococcus haemolyticus JCSC1435; Chlamydophila pneumoniae AR39; Borrelia burgdorferi B31; Chlamydia trachomatis D/UW-3/CX
    Type:
    Expression profiling by array
    Dataset:
    GDS3427
    Platform:
    GPL4692
    6 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE8041
    ID:
    200008041
    5.
    Full record GDS3427

    Rickettsia rickettsii virulent and avirulent strains

    Comparison of the Rickettsia rickettsii virulent strain Sheila Smith and the avirulent strain Iowa. R. rickettsii is an obligate intracellular pathogen that causes Rocky Mountain spotted fever. Results provide insight in the molecular basis of virulence in R. rickettsii.
    Organism:
    Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Chlamydophila pneumoniae AR39; Staphylococcus epidermidis RP62A; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Borrelia burgdorferi B31; Coxiella burnetii RSA 493; Chlamydophila caviae GPIC; Chlamydia trachomatis D/UW-3/CX; Staphylococcus haemolyticus JCSC1435; Granulibacter bethesdensis
    Type:
    Expression profiling by array, count, 2 strain sets
    Platform:
    GPL4692
    Series:
    GSE8041
    6 Samples
    Download data:
    GEO (CEL, CHP)
    6.

    Effect of heat shock on Rickettsia prowazekii Madrid E from four independent biological replicates

    (Submitter supplied) Here we present the first microarray analysis of global gene expression changes in the obligate intracytoplasmic pathogen Rickettsia prowazekii using temperature upshift as a model stress condition. We describe a methodology for isolating highly-purified rickettsial RNA where a combination of differential centrifugation and use of Ambion’s MICROBEnrich reagent removed the majority (~90 %) of host cell RNA. more...
    Organism:
    Rickettsia prowazekii str. Madrid E
    Type:
    Expression profiling by array
    Platform:
    GPL7134
    8 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE12377
    ID:
    200012377
    7.

    Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis

    (Submitter supplied) Geographical distinct virulent Babesia bovis strains have similar gene expression changes as they go through attenuation.
    Organism:
    Babesia bovis
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL17815
    6 Samples
    Download data:
    GEO (TXT), SRA SRP031834
    Series
    Accession:
    GSE51560
    ID:
    200051560
    8.

    Integrated analysis of omics profiles

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Protein profiling by protein array; Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
    Platforms:
    GPL9052 GPL10999 GPL14689
    62 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE33029
    ID:
    200033029
    9.

    Personal Omics Profiling Reveals Dynamic Molecular Phenotypes and Actionable Medical Risks

    (Submitter supplied) We have determined the whole genome sequence of an individual at high accuracy and performed an integrated analysis of omics profiles over a 1.5 year period that included healthy and two virally infected states. Omics profiling of transcriptomes, proteomes, cytokines, metabolomes and autoantibodyomes from blood components have revealed extensive, dynamic and broad changes in diverse molecular components and biological pathways that occurred during healthy and disease states. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
    Platforms:
    GPL9052 GPL10999
    25 Samples
    Download data:
    GEO (BAM), SRA SRP008976
    Series
    Accession:
    GSE32874
    ID:
    200032874
    10.

    Autoantibody profile timecourse of UNK

    (Submitter supplied) We have determined the whole genome sequence of an individual at high accuracy and performed an integrated analysis of omics profiles over a 1.5 year period that included healthy and two virally infected states. Omics profiling of transcriptomes, proteomes, cytokines, metabolomes and autoantibodyomes from blood components have revealed extensive, dynamic and broad changes in diverse molecular components and biological pathways that occurred during healthy and disease states. more...
    Organism:
    Homo sapiens
    Type:
    Protein profiling by protein array
    Platform:
    GPL14689
    37 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE32691
    ID:
    200032691

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