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    Results: 15

    1.
    Full record GDS3666

    SIRT1 deficiency effect on the liver

    Analysis of liver deficient for SIRT1. SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient availability. Results provide insight into the role of hepatic SIRT1 in fatty acid metabolsim.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 genotype/variation sets
    Platform:
    GPL7202
    Series:
    GSE14921
    6 Samples
    Download data:
    GEO (TIFF, TXT)
    2.

    Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism

    (Submitter supplied) Hepatic metabolic derangements are key components in the development of fatty liver, insulin resistance, and atherosclerosis. SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient availability. Here we demonstrate that hepatic SIRT1 regulates fatty acid metabolism by positively regulating PPAR-alpha. Hepatocyte-specific deletion of SIRT1 impairs PPAR-alpha signaling and decreased fatty acid beta-oxidation in the liver. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS3666
    Platform:
    GPL7202
    6 Samples
    Download data:
    GEO (TIFF, TXT)
    Series
    Accession:
    GSE14921
    ID:
    200014921
    3.

    SIRT4 KO livers microarray

    (Submitter supplied) Sirtuins are a family of protein deacetylases, deacylases, and ADP-ribosyltransferases that regulate life span, control the onset of numerous age-associated diseases, and mediate metabolic homeostasis. We have uncovered a novel role for the mitochondrial sirtuin SIRT4 in the regulation of hepatic lipid metabolism during changes in nutrient availability. We show that SIRT4 levels decrease in the liver during fasting and that SIRT4 null mice display increased expression of hepatic peroxisome proliferator activated receptor (PPAR ) target genes associated with fatty acid catabolism. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS4823
    Platform:
    GPL1261
    12 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE56321
    ID:
    200056321
    4.
    Full record GDS4823

    SIRT4 deficiency effect on the liver

    Analysis of livers from sirtuin 4 (SIRT4)-null, 129SV males. Fatty acid oxidation rates are higher in SIRT4 knockout hepatocytes than in wildtype cells. Results provide insight into the role of SIRT4 in hepatic lipid metabolism.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 genotype/variation sets
    Platform:
    GPL1261
    Series:
    GSE56321
    12 Samples
    Download data:
    GEO (CEL)
    5.

    lipin 1beta overexpression in mouse liver

    (Submitter supplied) Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld mice, a genetic model of lipodystrophy. Lipin 1 appears to be highly involved in the control of fatty acid metabolism. Lipin 1 is most often located in the nucleus, but other studies suggest that lipin also has effects in the cytoplasm. However, the molecular function of lipin 1 is unclear. To evaluate the effects of activation of the lipin 1 system in liver, lipin 1beta was overexpressed in mouse liver using an adenoviral vector. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS2291
    Platform:
    GPL339
    4 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE5538
    ID:
    200005538
    6.
    Full record GDS2291

    Lipin 1-beta overexpression effect on the liver

    Analysis of livers of transgenics overexpressing lipin 1-beta, an alternative form of lipin 1 containing a 33 amino acid insertion. Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld animals, a genetic model of lipodystrophy. Results provide insight into the function of lipin 1.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 genotype/variation sets
    Platform:
    GPL339
    Series:
    GSE5538
    4 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS2291
    ID:
    2291
    7.

    Nordihydroguaiaretic Acid Improves Metabolic Dysregulation and Aberrant Hepatic Lipid Metabolism in Mice by Both PPAR-alpha-Dependent and -Independent Pathways

    (Submitter supplied) To test whether NDGA attenuate dyslipidemia and hepatic steatosis by enhancing fatty acid oxidation through activation of PPAR-α. Using wild type (WT, C57BL/6) fed with chow diet as control, WT mice were either fed with high-fat diet or high-fat diet with NDGA (2.5g/kg food); ob/ob mice were fed with either chow or chow with NDGA (2.5 g/kg food), and maintained on the respective diets for 16 weeks. The expression of lipid metabolism related genes in the liver of these mice were analyzed using Phalanx GPL6845 platform (Mouse OneArray V1). Together with other biochemical/physiological data, our results suggest that the beneficial actions of NDGA on dyslipidemia and hepatic steatosis in ob/ob mice are exerted primarily through enhanced fatty acid oxidation and energy utilization via the activation of PPAR- α receptor activity.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6845
    5 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE35075
    ID:
    200035075
    8.

    Role of SIRT1 in diet-induced metabolic diseases

    (Submitter supplied) The purpose of this study is to investigate the role of SIRT1 in high-fat diet-induced liver steatosis and insulin resistance. SIRT1 is a nuclear enzyme that could remove an acetyl-group from target proteins by using NAD as co-substrate. Homologs of this protein in yeast and the roundworm C. elegans are able to delay the aging process in response to nutrients. However, the molecular mechanism by which SIRT1 sense the environment to mediate this response are poorly understood. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL4134
    12 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE39778
    ID:
    200039778
    9.

    PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism.

    (Submitter supplied) Peroxisome proliferator-activated receptor alpha (PPARα) is a key regulator of hepatic fat oxidation that serves as an energy source during starvation. Vanin-1 has been described as a putative PPARα target gene in liver, but its function in hepatic lipid metabolism is unknown. We investigated the regulation of vanin-1, and total vanin activity, by PPARα in mice and humans. Furthermore, the function of vanin-1 in the development of hepatic steatosis in response to starvation was examined in Vnn1 deficient mice, and in rats treated with an inhibitor of vanin activity. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL11533
    16 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE51712
    ID:
    200051712
    10.

    Identification of transcriptional changes due to loss of Hdac3 in liver at P17 and P28

    (Submitter supplied) Histone deacetylase 3 (Hdac3) is the enzymatic component of transcriptional repression complexes recruited by the nuclear hormone receptors. Inactivation of Hdac3 in cancer cell lines triggered apoptosis, and removal of Hdac3 in the germ-line of mice caused embryonic lethality. Therefore, we conditionally deleted the Hdac3 allele in the mouse liver. These mice developed hepatomegaly, which was the result of hepatocyte hypertrophy, and these morphological changes coincided with significant imbalances between carbohydrate and lipid metabolism. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL2995
    12 Samples
    Download data:
    GEO (XLS)
    Series
    Accession:
    GSE10503
    ID:
    200010503
    11.

    Gene expression profiles in Sirt1/PPARalpha bigenic mice

    (Submitter supplied) Cardiac-specific PPARalpha transgenic (Tg-PPARalpha) mice show mild cardiac hypertrophy and systolic dysfunction. The failing heart phenotypes observed in Tg-PPARalpha are exacerbated by crossing with cardiac-specific Sirt1 transgenic (Tg-Sirt1) mice, whereas Tg-Sirt1 mice themselves do not show any cardiac hypertrophy or systolic dysfunction. To investigate the mechanism leading to the failing heart phenotypes in TgPPARalpha/Tg-Sirt1 bigenic mice, microarray analyses were performed. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    8 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE33101
    ID:
    200033101
    12.

    Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting

    (Submitter supplied) Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein metabolism is not well studied. Here, we performed comparative polysome and associated transcriptional profiling analyses to study the dynamics and functional implications of endoplasmic reticulum (ER)-associated protein synthesis in the mouse liver under conditions of obesity and nutrient deprivation.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array; Other
    Dataset:
    GDS4506
    Platform:
    GPL1261
    10 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE39375
    ID:
    200039375
    13.
    Full record GDS4506

    Liver response to obesity and fasting

    Analysis of liver endoplasmic reticulum (ER)-associated polysomes from leptin deficient (ob/ob) males after overnight fasting. The liver is critical for metabolic homeostasis. Results provide insight into molecular mechanisms underlying changes in protein metabolism caused by obesity and diabetes.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 genotype/variation, 2 protocol sets
    Platform:
    GPL1261
    Series:
    GSE39375
    10 Samples
    Download data:
    GEO (CEL, CHP)
    14.

    High Fat Diet Triggers SIRT1 Cleavage in Adipose Tissue Providing a Link between Dietary Stress and Metabolic Dysfunction.

    (Submitter supplied) Adipose tissue plays an important role in storing excess nutrients and preventing ectopic lipid accumulation in other organs. Obesity leads to excess lipid storage in adipocytes, resulting in the generation of stress signals and the derangement of metabolic functions. SIRT1 is an important regulatory sensor of nutrient availability in many metabolic tissues. Here we report that SIRT1 functions in adipose tissue to protect from the development of inflammation and obesity under normal feeding conditions, and the progression to metabolic dysfunction under dietary stress. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    16 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE30247
    ID:
    200030247
    15.

    SIRT6 and SIRT1 contribute to circadian gene expression

    (Submitter supplied) Comparison of the hepatic circadian transcriptomes reveals that SIRT6 and SIRT1 separately control transcriptional specificity, and therefore, define distinctly partitioned classes of circadian genes.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL16570
    72 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE57830
    ID:
    200057830

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